Mogengel Matrix (HC) (Acro Certified) AC-M082724 ACROBiosystems
$290.00
In stock
SKU
AC-M082724
Key Benefits
Subcutaneous Tumorigenesis Assay Validated - Strict Quality Control Assays for every produced lot. Lot-to-lot Consistency - Strict manufacturing controls and management systems. Stable, Long-term Supply - Large-scale manufacturing capacity and ACRO’s global supply chain. Cost Effective - Bulk pricing available to meet your research needs.
Product Description
- Basement membranes are comprised of continuous sheets of a specialized extracellular matrix. It acts an interface between various types of cells, including muscle, neuronal, epithelial, or endothelial cells, along with adjacent stroma. Basement membranes are an essential part in the organization of tissues forming the scaffolding and support for cellular growth and cell layers. They also affect a variety of cellular mechanisms such as adhesion, migration, proliferation, and differentiation. Basement membranes are selectively degraded and regenerated during development and wound healing, forming the base scaffold for tissue reconstruction. Basement membranes also act as a major barrier to invasion by metastatic tumor cells.
- Mogengel Matrix (HC) (High Concentration) is a soluble form of basement membrane that is purified from gene-edited mouse tumor cells grown in LDEV-free mouse populations. Reconstitution into the original basement membrane form occurs at 37℃and is mainly comprised of laminin, collagen IV, entactin, and heparin sulfate proteoglycan.
Specification
| Protein Concentration | ≥16 mg/mL, tested by BCA assay. |
| Endotoxin Level | ＜4.5 EU/mL, tested by LAL assay. |
| Subcutaneous Tumor Xenograft | Subcutaneous tumor formation with the addition of Mogengel Matrix (HC GFR) to promote proliferation of tumor cells. *Evaluated Mogengel Matrix Ratio > 50%. |
| Angiogenesis | Blood vessel formation is observed, tested by HUVEC angiogenesis assay. *Evaluated Mogengel Matrix: Medium Ratio = 1:0 (original formulation), 2:1, 1:1 (v/v). |
| Sterility | No growth observed after 14 days. Testing for the detection of bacteria, fungi, and mycoplasma through cell culture. |
| Viral Testing | Tested negative by ELISA, bacterial culture and microscope observation for a total of 19 bacterial and virus strains, and additional murine infectious agents including LDEV. |
| Stability | Product is stable for at least two years from date of manufacture when stored at ≤-20℃ See lot specific Certificate of Analysis for expiration date. |
| Shipping Conditions | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label. |
| Storage | Store at -20℃ Avoid multiple freeze-thaws. Do not store in frost-free freezer. KEEP FROZEN. |
Product Details
| Intended Use | Mogengel Matrix (HC) is intended to be used for in vivo experiments, including patient-derived xenografts, cell-derived xenografts, as well as in vitro angiogenesis assays. |
Acro Certify Disclaimer
This product is one of ACROBiosystems' Certify products. ACROBiosystems and our Certify partners have established a close partnership that includes an in-depth review of quality management and quality audits this product. Products from our Certify partners have been qualified by ACROBiosystems to be included under Acro Certify. ACROBiosystems may provide Product information, including technical information, specifications, recommendations, literature, and other material (collectively, "Product Information") for customer's convenience. The accuracy and completeness of Product Information is not guaranteed and is subject to change without notice. ACROBiosystems is not responsible for the intellectual property or impact to intellectual property for products sold under Acro Certify.
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