GMP Salt Active GENIUS?Nuclease DMF Salt-Active GENIUS Nuclease, GMP-grade ACROBiosystems
$670.00
In stock
SKU
Salt-Active GENIUS Nuclease, GMP-grade
GMP Platform Advantages
- Quality Assurance : Global QMS with comprehensive and stringent QC release criteria.
- End-to-End GMP Compliance : Full manufacturing and QC under a cGMP system.
- Comprehensive Control of Adventitious Agents : Stringent biosafety from cell banks to final release.
- Comprehensive Regulatory Support : Includes RSF and DMF to meet global requirements.
- Resilient Supply Chain : Intelligent modular facilities ensure a stable global supply.
- Professional Support : Extensive manufacturing and application expertise to accelerate development.
Product Details
GMP Salt Active GENIUS?Nuclease is developed with ACRObiosystems' unique enzyme AI evolution platform based on wild-type Serratia marcescens endonuclease. It is capable of maintaining high specific activity to effectively degrade nucleic acids in any form across a broad salt concentration range (0-500 mM NaCl), especially high salt up to 500mM NaCl, which makes it suitable for nucleic acid removal in processes that of higher salt conditions. The enzyme is a non-specific nuclease with high specific activity, degrading single- and double-stranded nucleic acids in any form (single stranded, double stranded, linear, circular, and supercoiled). It hydrolyzes internal phosphodiester bonds present between the nucleotides to 5’- phosphorylated oligonucleotides of 3-5 bases in length.
Vial Specification
2R (13 mm neck finish)
MANUFACTURING SPECIFICATIONS
- SDS-PAGE
- Protein content
- Endotoxin level
- Residual Host Cell DNA content
- Residual Host Cell Protein content
- Biological activity analysis
- Microbial testing
- Mycoplasma testing
- In vitro virus assay
- Batch-to-batch consistency
Product Details
| Application | Elimination of nucleic acids from biologics, suitable for samples with 0-500 mM salt in presence of 5-10 mM Mg++ ? clinical viral vaccine production ? clinical viral vector production for cell and gene therapy (CGT) ? Other clinical development and production uses |
| Purity | >95% as determined by SDS-PAGE. >95% as determined by SEC-HPLC. |
| Enzyme Activity | ＞250 U/μL |
| Host Cell Protein | <0.05 ng/?g of protein tested by ELISA. |
| Protease Activity | Negative |
| Sterility | Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1. |
| Mycoplasma | Negative |
| Endotoxin | Less than 10 EU/mg, tested by the LAL method in compliance with USP <85> and Ph. Eur. 2.6.14. |
| Formulation | Supplied as 0.2 μm filtered solution in 25 mM Tris, 500 mM NaCl, 5 mM MgCl2, pH7.5. Contact us for customized product form or formulation. |
| Shipping | This product is supplied and shipped with dry ice, please inquire the shipping cost. |
Storage
- The product MUST be stored at -20°C or lower upon receipt;
- -20°C for 5 years under sterile conditions.
ACROBIOSYSTEMS - LEGAL NOTICES FOR GMP GRADE PRODUCTS
ACRO has the right, at its sole discretion, to modify, add or remove any terms herein without notice to Purchaser and/or End User. Any changes to these terms are effective immediately following the updating of such changes on ACRO’s website or published specifications or product-related documents.
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