GMP GENPower? NLS-Cas9 Nuclease DMF NLS-Cas9 Nuclease, GMP-grade ACROBiosystems
$8,550.00
In stock
SKU
NLS-Cas9 Nuclease, GMP-grade
GMP Platform Advantages
- Quality Assurance : Global QMS with comprehensive and stringent QC release criteria.
- End-to-End GMP Compliance : Full manufacturing and QC under a cGMP system.
- Comprehensive Control of Adventitious Agents : Stringent biosafety from cell banks to final release.
- Comprehensive Regulatory Support : Includes RSF and DMF to meet global requirements.
- Resilient Supply Chain : Intelligent modular facilities ensure a stable global supply.
- Professional Support : Extensive manufacturing and application expertise to accelerate development.
Product Details
GMP GENPower? NLS-Cas9 Nuclease is a recombinant Streptococcus pyogenes Cas9 protein purified from Escherichia coli for CRISPR-based genome editing. The introduction of nuclear localization signals (NLS) can help Cas9 enter the nucleus, increasing the chance of genomic DNA cleavage.
Vial Specification
2R (13 mm neck finish)
MANUFACTURING SPECIFICATIONS
- SDS-PAGE
- Protein content
- Endotoxin level
- Residual Host Cell DNA content
- Residual Host Cell Protein content
- Biological activity analysis
- Microbial testing
- Mycoplasma testing
- In vitro virus assay
- Batch-to-batch consistency
Product Details
| Application | ? Genetic modification of cells and gene therapy drugs (T cell, hematopoietic stem cell) ? High specificity detection of pathogens |
| Concentration | 10 mg/mL |
| Purity | >95% as determined by SDS-PAGE. >95% as determined by SEC-HPLC. |
| Host Cell Protein | ≤10 ng/mg of protein tested by ELISA. |
| Host Cell DNA | ≤1 ng/mg of protein tested by qPCR. |
| Sterility | Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1. |
| Endotoxin | Less than 10 EU/mg, tested by the LAL method in compliance with USP <85> and Ph. Eur. 2.6.14. |
| Formulation | Supplied as 0.2 μm filtered solution in 20 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM TCEP, pH7.5. Contact us for customized product form or formulation. |
| Shipping | This product is supplied and shipped with dry ice, please inquire the shipping cost. |
Storage
- The product MUST be stored at -20°C or lower upon receipt;
- -20°C for 5 years under sterile conditions.
ACROBIOSYSTEMS - LEGAL NOTICES FOR GMP GRADE PRODUCTS
ACRO has the right, at its sole discretion, to modify, add or remove any terms herein without notice to Purchaser and/or End User. Any changes to these terms are effective immediately following the updating of such changes on ACRO’s website or published specifications or product-related documents.
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