| Catalog No. | Size | Price (USD) |
| rp148162-10μg | 10μg | $105.90 |
| rp148162-50μg | 50μg | $319.90 |
| rp148162-100μg | 100μg | $511.90 |
| rp148162-1mg | 1mg | $3,339.90 |
Product Information
| Product Name | Recombinant Human LAIR1 Protein |
| Short Description | Animal Free, ≥95% (SDS-PAGE), Active, 293F, C-His tag, 22-163 aa |
| Species | Human |
| Expressed Host | HEK293 |
| Accession | Q6GTX8 |
| Amino Acids | 22-163 aa |
| Protein TAG | C-His |
| Form | Liquid |
| Specifications & Purity | Animal Free,Carrier Free,Bioactive,ActiBioPure™,High Performance,His-Tag,≥95%(SDS-PAGE) |
| Endotoxin Concentration | <0.1 EU/μg |
| Biological Activity | Measured by the ability of the immobilized protein to support the adhesion of HeLa human cervical epithelial carcinoma cells. The ED50 for this effect is 0.25-1.0 μg/mL. |
| SDS Page | 20 - 34 kDa, under reducing conditions; 20 - 34 kDa, under non-reducing conditions. |
| Sequence | QEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERDSRSTYNDTEDVSQASPSESEARFRIDSVREGNAGLYRCIYYKPPKWSEQSDYLELLVKESSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEHHHHHHH |
| Synonyms | CD305 | CD305 antigen | CD305leukocyte-associated Ig-like receptor 1 | HLAIR1 | LAIR1 | LAIR-1 | leukocyte-associated immunoglobulin-like receptor 1 |
Product Description
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells.
Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Reconstitution
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
Storage and Shipping
| Shipped In | Ice chest + Ice pads |
| Stability and Storage | Store at -20~-80℃ for more than 1 year. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
