Citations：739
| CAS：58-58-2 | Molecular Formula：C22H29N7O5·2HCl |
| Molecular Weight：544.44 | Storage：Store at -20℃，4 years |
| Appearance：White to light yellow powder | Purity：99% |
| Name Puromycin | CAS 58-58-2 |
| Molecular Formula C22H29N7O5·2HCl | Molecular Weight 544.44 |
| Storage Store at -20℃，4 years | Specification 100mg ; 25mg |
| Appearance White to light yellow powder | Purity 99% |
| Grade BR | Solubility 50 mg/mL in Water |
| Hazard Code R:22 | Description: |
| Puromycin is an aminoglycoside antibiotic produced by the fermentative metabolism of Streptomyces alboniger that kills Gram-positive bacteria, various animal and insect cells by inhibiting protein synthesis. Escherichia coli is effective in certain cases. The mechanism of action is that purinomycin is an analogue of the 6 'terminal of the aminoacyl-trNA molecule, which binds to the A site of the ribosome and is incorporated into the extended peptide chain. After binding to the A site, purinomycin does not participate in any subsequent reaction, resulting in early termination of protein synthesis and the release of immature peptides containing purinomycin at the C-terminal. | The widespread application of purinomycin in the screening of cell stable strains is related to the characteristics of lentiviral vectors, and most of the commercial lentiviral vectors carry pac gene. In some specific cases, purinomycin can also be used to screen for transformation of E. coli strains carrying pac gene plasmids. |
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