Recombinant Human Membrane cofactor protein (CD46), partial (Active) CSB-MP004939HU CUSABIO
$9.90
In stock
SKU
CSB-MP004939HU
Product Details
| Uniprot No. | P15529 |
| Alternative Names | CD46; MCP; MIC10; Membrane cofactor protein; TLX; Trophoblast leukocyte common antigen; CD antigen CD46 |
| Species | Homo sapiens (Human) |
| Source | Mammalian cell |
| Expression Region | 35-328aa |
| Purity | Greater than 90% as determined by SDS-PAGE. Greater than 95% as determined by SEC-HPLC. |
| Endotoxin | Less than 1.0 EU/ug as determined by LAL method. |
| Activity | Measured by its binding ability in a functional ELISA. Immobilized CD46 at 2 μg/ml can bind Anti-CD46 rabbit monoclonal antibody, the EC50 of human CD46 protein is 0.8333-1.054 ng/ml. |
| Tag Info | C-terminal hFc1-tagged |
| Form | Liquid or Lyophilized powder |
| Buffer | Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4 |
| Troubleshooting and FAQs | Protein FAQs |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time. Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged. |
| Target Names | CD46 |
| Research Area | Cancer |
| Target Protein Sequence | CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPRPTYKPPVSNY |
| Mol. Weight | 61.6 kDa |
| Protein Length | Partial |
| Storage Condition | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| Shelf Life | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Datasheet & COA | Please contact us to get it. |
| Description | CD46 functions as a critical complement regulatory protein that protects host cells from autologous complement attack, making it a key target in cancer immune evasion research. This recombinant human CD46 construct (residues 35–328) carries a C-terminal hFc1 tag and demonstrates robust functional activity, with an EC50 of 0.83–1.05 ng/ml in binding ELISA against anti-CD46 monoclonal antibody, supporting its use as a positive control in complement ELISA and as a reliable reagent for inhibitor screening targeting complement pathways. The protein's mammalian expression ensures native-like glycosylation critical for complement regulatory function, while endotoxin levels below 1.0 EU/μg and purity exceeding 90% by SDS-PAGE satisfy the stringent criteria required for hemolytic assays, opsonization studies, and mechanistic investigations of tumor immune evasion where background inflammatory signals would confound results. |
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
