CXCR4 Recombinant Monoclonal Antibody CSB-RA569311A0HU CUSABIO
$210.00
In stock
SKU
CSB-RA569311A0HU
Product Details
| Uniprot No. | P61073 |
| Alternative Names | CXCR4; C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD antigen CD184 |
| Species Reactivity | Human |
| Immunogen Species | Homo sapiens (Human) |
| Immunogen | A synthesized peptide derived from human CXCR4 |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Purification Method | Affinity-chromatography |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Form | Liquid |
| Buffer | Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Tested Applications | ELISA, IF |
| Recommended Dilution | headers: Application; Recommended Dilution; rows: Application: IF; Recommended Dilution: 1:20-1:200 |
| Troubleshooting and FAQs | Antibody FAQs |
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
| Usage | For Research Use Only. Not for use in diagnostic or therapeutic procedures. |
| Target Names | CXCR4 |
| Conjugate | Non-conjugated |
| Clone No. | 2F10 |
| Protocols | ELISA Protocol Immunofluorescence (IF) Protocol |
| Description | CXCR4, also known as CD184 or fusin, is a seven-transmembrane G protein-coupled receptor that serves as the primary receptor for stromal cell-derived factor 1 (SDF-1/CXCL12). This chemokine receptor plays a central role in leukocyte trafficking, hematopoietic stem cell homing, and embryonic development. Beyond its physiological functions, CXCR4 has garnered significant research attention for its involvement in cancer metastasis, where the CXCR4-SDF-1 axis guides tumor cell migration to secondary sites, and in HIV infection, where it functions as a co-receptor for viral entry. This recombinant monoclonal antibody, clone 2F10, was generated against a synthetic peptide derived from human CXCR4 and produced in rabbit host. The recombinant format ensures consistent performance across experiments, eliminating the lot-to-lot variability that can complicate long-term studies or multi-site collaborations. With a sequence-defined binding region, you can confidently compare results over time and across different experimental setups. The antibody has been validated for immunofluorescence applications, where it successfully detected CXCR4 in HeLa cells at dilutions ranging from 1:20 to 1:200. In these experiments, cells were fixed with formaldehyde, permeabilized with Triton X-100, and visualized using FITC-conjugated secondary antibodies, demonstrating clear membrane and cytoplasmic staining patterns consistent with CXCR4 localization. This antibody supports investigations across multiple disciplines, including cancer biology, immunology, neuroscience, stem cell research, and microbiology. Whether you are studying chemokine-mediated cell migration, characterizing tumor microenvironments, or investigating stem cell trafficking mechanisms, this recombinant antibody provides the reliability needed for reproducible immunofluorescence-based detection of human CXCR4. |
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