| Size | Price (USD) |
| 100Tests | $57.00 |
| 50Tests | $32.00 |
| 100Tests×2 | $86.00 |
Product Details
| Abbre | CD54 |
| Synonyms | CD54, Icam-1, Icam1, Intercellular adhesion molecule 1, MALA-2, MyD10 |
| Swissprot | P13597 |
| Reactivity | Mouse |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | YN1/1.7.4 |
| Isotype | Rat IgG2b, κ |
| Isotype Control | Elab Fluor ® 647 Rat IgG2b, κ Isotype Control[LTF-2] |
| Applications | FCM |
| Conjugation | Elab Fluor ® 647 |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Research Areas | Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Stem Cells |
| Cellular Localization | Membrane |
Product Description
Conjugation Information: Elab Fluor ® 647 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 670 nm (e.g., a 660/20 nm bandpass filter).
Background: CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.
Storage and Shipping
| Storage | This product can be stored at 2-8°C for 24 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
