| Size | Price (USD) |
| 100μg | $88.00 |
| 100mg | $3,214.00 |
| 50mg | $2,236.00 |
| 25mg | $1,338.00 |
| 5mg | $512.00 |
| 1mg | $142.00 |
Product Details
| Abbre | CD54 |
| Synonyms | CD54, Icam-1, Icam1, Intercellular adhesion molecule 1, MALA-2, MyD10 |
| Swissprot | P13597 |
| Reactivity | Mouse |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | YN1/1.7.4 |
| Isotype | Rat IgG2b, κ |
| Applications | FCM |
| Conjugation | None (AF/LE) |
| Concentration | ≥ 1 mg/mL |
| Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Purification Method | >98%, Protein A/G purified |
| Immunogen | Recombinant Mouse CD54 protein |
| Research Areas | Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Stem Cells |
Product Description
Background: CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.
Storage and Shipping
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Shipping | Ice bag |
Additional Information
| Verified Samples | Verified Samples in FCM: C57/BL6 Mouse splenocytes |
| Dilution | FCM 2 μg/mL(0.5×10^6 -1×10^6 cells) |
