| Size | Price (USD) |
| 100Tests | $285.00 |
| 20Tests | $120.00 |
| 100Tests×2 | $425.00 |
Product Details
| Abbre | CD196/CCR6 |
| Synonyms | CMKBR6, GPR29, STRL22, CKRL3, GPRCY4, CCR6 |
| Swissprot | P51684 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | G034E3 |
| Isotype | Mouse IgG2b, κ |
| Isotype Control | Elab Fluor ® 700 Mouse IgG2b, κ Isotype Control[MPC-11] |
| Applications | FCM |
| Conjugation | Elab Fluor ® 700 |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Cellular Localization | Membrane |
Product Description
Conjugation Information: Elab Fluor ® 700 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 719 nm (e.g., a 725/40 nm bandpass filter).
Background: CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.
Storage and Shipping
| Storage | This product can be stored at 2-8°C for 24 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
