Product Details
| Abbre | CD135 |
| Synonyms | FMS-like tyrosine kinase-3, FLT-3, STK-1, Flk-2 |
| Swissprot | P36888 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BV10(BV10A4) |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Elab Fluor ® 647 Mouse IgG1, κ Isotype Control[MOPC-21] |
| Applications | FCM |
| Conjugation | Elab Fluor ® 647 |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Cellular Localization | Membrane |
Product Description
Conjugation Information: Elab Fluor ® 647 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 670 nm (e.g., a 660/20 nm bandpass filter).
Background: CD135 is a 130-160 kD type III tyrosine kinase receptor expressed on CD34+ hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. CD135 is also expressed on malignant hematopoietic cells including AML, ALL and CML-BC. CD135, also known as FMS-like tyrosine kinase-3, FLT3, STK-1, and Flk-2, is a growth factor receptor that binds the FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells. The intracytoplasmic domain of CD135 is modified by phosphorylation and has been shown to interact with Grb2, SOCS1, VAV1, and Shc.
Storage and Shipping
| Storage | This product can be stored at 2-8°C for 24 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |