Recombinant Superoxide Dismutase 1 Monoclonal Antibody (E-AB-81608) elabscience
$260.00
In stock
SKU
E-AB-81608
| Size | Price (USD) |
| 100μL | $260.00 |
| 50μL | $160.00 |
Product Details
| Abbre | Superoxide Dismutase 1 |
| Synonyms | ALS, ALS1, Amyotrophic lateral sclerosis 1 adult, Cu/Zn SOD, Cu/Zn superoxide dismutase, Epididymis secretory protein Li 44, HEL S 44, Homodimer, IPOA, Indophenoloxidase A, Mn superoxide dismutase, SOD, SOD soluble, SOD1, SOD2, SODC, Superoxide dismutase [Cu-Z, hSod1 |
| Swissprot | P00441 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Rabbit Monoclonal |
| Clone | R08-5A5 |
| Isotype | IgG |
| Applications | WB, IHC-P |
| Conjugation | Unconjugated |
| Concentration | 300 μg/mL |
| Buffer | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% stabilizer and 0.05% protective protein. |
| Purification Method | Affinity Purified |
| Immunogen | A synthetic peptide of human Superoxide Dismutase 1 |
| Calculated MW | 16 kDa |
| Observed MW | 16 kDa Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include: 1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein. 2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes. 3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1. 4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids). 5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers. If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane. |
| Research Areas | Cancer, Cell Biology, Metabolism, Signal Transduction |
| Cellular Localization | Cytoplasm. The pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. |
Product Description
Background: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body.The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide.The other isozyme is a mitochondrial protein.Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis.Rare transcript variants have been reported for this gene.
Storage and Shipping
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Additional Information
| Verified Samples | Verified Samples in WB: A549, HL-60, C6 Verified Samples in IHC: Human breast cancer |
| Dilution | WB 1:500-1:1000, IHC 1:50-1:100 |
- Biological responses of human cell lines to biochar dusts from different biomasses
Journal: Journal of Environmental Sciences | Year: 2025 | Impact Factor: 6.300
DOI: 10.1016/j.jes.2025.08.005 | Reactivity: Human | Sample Type: HaCaT cell,MRC5 cell - Quercetin encapsulated polycaprolactone-polyvinylpyrrolidone electrospun membranes as a delivery system for wound healing applications
Journal: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | Year: 2024 | Impact Factor: 4.400
DOI: 10.1016/j.ejpb.2024.114314 | Reactivity: Human | Sample Type: HaCaT cell
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