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RNF5 Polyclonal Antibody (E-AB-18788) elabscience

RNF5 Polyclonal Antibody (E-AB-18788) elabscience

Name: RNF5 Polyclonal Antibody (E-AB-18788) elabscience
SKU: E-AB-18788
Price: 399 USD
Availability: InStock

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$399.00

In stock

SKU

E-AB-18788

Size	Price (USD)
200μL	$399.00
120μL	$240.00
60μL	$143.00
20μL	$73.00

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Product introduction

Product Details

Abbre	RNF5
Synonyms	E3 ubiquitin protein ligase RNF5, E3 ubiquitin-protein ligase RNF5, G16, HsRma1, NG2, OTTHUMP00000029107, Protein G16, RING finger protein 5, RING5, RMA1, RNF 5, RNF5, Ram1 homolog
Swissprot	Q99942
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Applications	WB, IHC
Conjugation	Unconjugated
Concentration	0.66 mg/mL
Buffer	Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method	Antigen affinity purification
Immunogen	Fusion protein of human RNF5
Calculated MW	20 kDa
Observed MW	Refer to figures The actual band is not consistent with the expectation. Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include: 1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein. 2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes. 3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1. 4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids). 5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers. If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane.
Research Areas	Cancer, Cell Biology, Immunology, Microbiology
Cellular Localization	Membrane. Mitochondrion membrane. Endoplasmic reticulum membrane. Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.

Product Description

Background: The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.

Storage and Shipping

Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping	The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Additional Information