| Size | Price (USD) |
| 100Tests | $174.00 |
| 20Tests | $66.00 |
| 100Tests×2 | $264.00 |
Product Details
| Abbre | CD279/PD-1 |
| Synonyms | PD1, PDCD1, Protein PD-1, hPD-1 |
| Swissprot | Q15116 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | EH12.2H7 |
| Isotype | Mouse IgG1, κ |
| Isotype Control | FITC Mouse IgG1, κ Isotype Control[MOPC-21] |
| Applications | FCM |
| Conjugation | FITC |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Research Areas | Cancer Biomarkers, Immunology, Inhibitory Molecules |
| Cellular Localization | Membrane |
Product Description
Conjugation Information: FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter).
Background: Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
Storage and Shipping
| Storage | This product can be stored at 2-8°C for 24 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
