| Size | Price (USD) |
| 100μg | $88.00 |
| 100mg | $3,214.00 |
| 50mg | $2,236.00 |
| 25mg | $1,338.00 |
| 5mg | $512.00 |
| 1mg | $142.00 |
Product Details
| Abbre | PD-L1 |
| Synonyms | B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, B7-H, B7-H1, Programmed cell death ligand 1 |
| Swissprot | Q9NZQ7 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 29E.2A3 |
| Isotype | Mouse IgG2b, κ |
| Applications | FCM |
| Conjugation | None (AF/LE) |
| Concentration | ≥ 1 mg/mL |
| Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Purification Method | >98%, Protein A/G purified |
| Immunogen | Recombinant Human PD-L1 protein |
| Research Areas | Cancer Biomarkers, Costimulatory Molecules, Immunology |
Product Description
Background: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.
Storage and Shipping
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Shipping | Ice bag |
Additional Information
| Verified Samples | Verified Samples in FCM: Human peripheral blood lymphocytes |
| Dilution | FCM 2 μg/mL(0.5×10^6 -1×10^6 cells) |
