PE Anti-Mouse/Rat Foxp3 Antibody[FJK-16s] (E-AB-F1351UD) elabscience
$300.00
In stock
SKU
E-AB-F1351UD
| Size | Price (USD) |
| 100μg | $300.00 |
| 25μg | $140.00 |
Product Details
| Abbre | Foxp3 |
| Synonyms | IPEXJM2ScurfinZinc finger protein JM2, Forkhead box protein P3 |
| Swissprot | Q99JB6 |
| Reactivity | Mouse, Rat |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | FJK-16s |
| Isotype | Rat IgG2a, κ |
| Isotype Control | PE Rat IgG2a, κ Isotype Control[2A3] |
| Applications | ICFCM |
| Conjugation | PE |
| Concentration | 0.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Research Areas | Immunology |
| Cellular Localization | Nucleus;Cytoplasm |
Product Description
Conjugation Information: PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter).
Background: FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4<sup>+</sup>/CD25<sup>-</sup> cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity.
Storage and Shipping
| Storage | This product can be stored at 2-8°C for 24 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
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