| Size | Price (USD) |
| 100Tests | $285.00 |
| 20Tests | $115.00 |
| 100Tests×2 | $425.00 |
Product Details
| Abbre | CD197/CCR7 |
| Synonyms | EBI1EVI1, CCR-7, CDw197, CMKBR7 |
| Swissprot | P32248 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | G043H7 |
| Isotype | Mouse IgG2a, κ |
| Isotype Control | PE/Cyanine5.5 Mouse IgG2a, κ Isotype Control[C1.18.4] |
| Applications | FCM |
| Conjugation | PE/Cyanine 5.5 |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Research Areas | Immunology |
| Cellular Localization | Membrane |
Product Description
Conjugation Information: PE/Cyanine5.5 is designed to be excited by the Blue (488 nm), Green (532 nm) and yellow-green (561 nm) lasers and detected using an optical filter centered near 690 nm (e.g., a 690/50 nm bandpass filter).
Background: CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.
Storage and Shipping
| Storage | This product can be stored at 2-8°C for 24 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
