| Size | Price (USD) |
| 100Tests | $260.00 |
| 20Tests | $110.00 |
| 100Tests×2 | $425.00 |
Product Details
| Abbre | CD158b/j |
| Swissprot | P43627 P43628 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | DX27 |
| Isotype | Mouse IgG2a, κ |
| Isotype Control | PE/Cyanine7 Mouse IgG2a, κ Isotype Control[C1.18.4] |
| Applications | FCM |
| Conjugation | PE/Cyanine 7 |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Cellular Localization | Membrane |
Product Description
Conjugation Information: PE/Cyanine7 is designed to be excited by the Blue (488 nm), Green (532 nm) and yellow-green (561 nm) lasers and detected using an optical filter centered near 775 nm (e.g., a 780/60 nm bandpass filter).
Background: CD158b is expressed on natural killer cells and a subset of T cells. It is a member of the immunoglobulin superfamily containing two immunoglobulin C2-type domains. Both variants and alternative isoforms of CD158b have been reported. The interaction of CD158b with specific HLA-C antigens on a target cell (HLA-Cw1, HLA-Cw3, HLA-Cw7 alleles, for example) inhibits cytotoxicity and prevents target cell lysis and death. The interactions between KIR and MHC class I are thought to be important in NK cell and T cell regulation following antigen stimulation. The absence of ligands for KIRs may lower the threshold for activation through activating receptors and increase inflammation and susceptibility to autoimmune disease.
Storage and Shipping
| Storage | This product can be stored at 2-8°C for 24 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
