Biotin Anti-Mouse CD22 Antibody[Cy34.1] (E-AB-F1021B) elabscience
$68.00
In stock
SKU
E-AB-F1021B
| Size | Price (USD) |
| 100μg | $68.00 |
| 25μg | $30.00 |
Product Details
| Abbre | CD22 |
| Synonyms | Siglec2, B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, CD22, Cd22, Lyb-8, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14 |
| Swissprot | P35329 |
| Reactivity | Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | Cy34.1 |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Biotin Mouse IgG1, κ Isotype Control[MOPC-21] |
| Applications | FCM |
| Conjugation | Biotin |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Research Areas | Immunology |
| Cellular Localization | Membrane |
Product Description
Background: The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.
Storage and Shipping
| Storage | This product can be stored at 2-8°C for 24 months. Do not freeze. |
| Shipping | Ice bag |
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