ATM Polyclonal Antibody (E-AB-66517) elabscience
$530.00
In stock
SKU
E-AB-66517
| Size | Price (USD) |
| 200μL | $530.00 |
| 120μL | $320.00 |
| 60μL | $200.00 |
Product Details
| Abbre | ATM |
| Synonyms | AT1, ATA, ATC, ATD, ATDC, ATE, ATM, TEL1, TELO1 |
| Swissprot | Q13315 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Applications | IF |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Immunogen | A synthetic peptide of human ATM (NP_000042.3). |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Cellular Localization | Nucleus. Cytoplasmic vesicle. Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin. |
Product Description
Background: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Storage and Shipping
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Additional Information
| Verified Samples | Verified Samples in IF: U2OS |
| Dilution | IF 1:50-1:200 |
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