BECN1 Polyclonal Antibody (E-AB-53242) elabscience
$399.00
In stock
SKU
E-AB-53242
| Size | Price (USD) |
| 200μL | $399.00 |
| 120μL | $240.00 |
| 60μL | $143.00 |
| 20μL | $73.00 |
Product Details
| Abbre | BECN1 |
| Synonyms | APG6, ATG 6, ATG6, ATG6 autophagy related 6 homolog, BECN 1, BECN1, Bcl-2-interacting protein beclin, Beclin 1 (coiled coil moesin like BCL2 interacting protein), Beclin 1 autophagy related, Beclin-1, Beclin1, Becn1, C, Coiled coil myosin like BCL2 interacting protein |
| Swissprot | Q14457 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Applications | WB, IHC |
| Conjugation | Unconjugated |
| Concentration | 0.84 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Immunogen | Synthetic peptide of human BECN1 |
| Calculated MW | 52 kDa |
| Observed MW | Refer to figures The actual band is not consistent with the expectation. Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include: 1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein. 2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes. 3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1. 4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids). 5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers. If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane. |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Metabolism, Microbiology, Signal Transduction |
| Cellular Localization | Golgi apparatus>trans-Golgi network membrane. Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells. |
Product Description
Background: Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
Storage and Shipping
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Additional Information
| Verified Samples | Verified Samples in WB: 293T, Raji Verified Samples in IHC: Human prostate cancer, Human tonsil |
| Dilution | WB 1:500-1:2000, IHC 1:50-1:100 |
- Age-related adiponectin resistance in human skeletal muscle dysfunction: in vivo and in vitro evidence
Journal: Journal of Translational Medicine | Year: 2026 | Impact Factor: 7.500
DOI: 10.1186/s12967-026-07959-9 | Reactivity: Human | Sample Type: Skeletal Muscle Cell - Synergistic targeting of the HIF-1α/autophagy axis sensitizes hypoxic MCF-7 breast cancer cells to apoptosis via PTEN upregulation and Bcl-2 collapse
Journal: PHARMACIA | Year: 2026 | Impact Factor: 1.500
DOI: 10.3897/pharmacia.73.e190219 | Reactivity: Human | Sample Type: MCF-7 cell - Autophagic Impairment in Endometrial Polyps: A Potential Biomarker and Therapeutic Target
Journal: TISSUE & CELL | Year: 2025 | Impact Factor: 2.700
DOI: 10.1016/j.tice.2025.102978 | Reactivity: Human | Sample Type: endometrial tissue - Investigation of the effects of umbilical cord and adipose-derived mesenchymal stem cells on endoplasmic reticulum stress in cadmium-induced rat kidney
Journal: Advances in Medical Sciences | Year: 2025 | Impact Factor: 2.600
DOI: 10.1016/j.advms.2025.07.002 | Reactivity: Rat | Sample Type: kidney tissue - Evidence that tirzepatide protects against diabetes-related cardiac damages
Journal: Cardiovascular Diabetology | Year: 2024 | Impact Factor: 9.300
DOI: 10.1186/s12933-024-02203-4 | Reactivity: Human | Sample Type: AC16 cell - Deciphering pancreatic neuroendocrine tumors: Unveiling through circulating small extracellular vesicles
Journal: Heliyon | Year: 2024 | Impact Factor: 3.400
DOI: 10.1016/j.heliyon.2024.e29079 | Reactivity: Human | Sample Type: small extracellular vesicles (sEV) - Rs1347093 regulates microRNA-216/-217 expression and is associated with pancreatic cancer risk
Journal: PANCREATOLOGY | Year: 2024 | Impact Factor: 2.800
DOI: 10.1016/j.pan.2024.10.004 | Reactivity: Human | Sample Type: AsPC-1 cell,BxPC-3 cell,PANC-1 cell - Vitamin D may assist the UPR against sodium fluoride-induced damage by reducing RIPK1, ATG5, BECN1, oxidative stress and increasing Caspase-3 in the osteoblast MC3T3-E1 cell line
Journal: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | Year: 2023 | Impact Factor: 3.500
DOI: 10.1016/j.jtemb.2023.127293 | Reactivity: Mouse | Sample Type: MC3T3-E1 cell - Infliximab Ameliorates Methotrexate-Induced Nephrotoxicity in Experimental Rat Model: Impact on Oxidative Stress, Mitochondrial Biogenesis, Apoptotic and Autophagic Machineries
Journal: CELL BIOCHEMISTRY AND BIOPHYSICS | Year: 2023 | Impact Factor: 2.600
DOI: 10.1007/s12013-023-01168-7 | Reactivity: Rat | Sample Type: renal tissue - Evaluation of the therapeutic effects of calcium dobesilate in sciatic nerve crush injury in rats
Journal: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | Year: 2022 | Impact Factor: 2.687
DOI: 10.1016/j.injury.2022.08.061 | Reactivity: Rat | Sample Type: sciatic nerve - Investigation of therapeutic effects of calcium dobesilate in cerebral hypoxia/ reperfusion injury in rats
Journal: NEUROLOGICAL RESEARCH | Year: 2022 | Impact Factor: 2.529
DOI: 10.1080/01616412.2022.2159109 | Reactivity: Rat | Sample Type: brains - Strophanthidin Attenuates MAPK, PI3K/AKT/mTOR, and Wnt/β-Catenin Signaling Pathways in Human Cancers
Journal: Frontiers in Oncology | Year: 2020 | Impact Factor: 4.848
DOI: 10.3389/fonc.2019.01469 | Reactivity: Human | Sample Type: MCF-7 cell, A549 cell, HepG2 cell
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