CBL Polyclonal Antibody (E-AB-63260) elabscience
$530.00
In stock
SKU
E-AB-63260
| Size | Price (USD) |
| 200μL | $530.00 |
| 120μL | $320.00 |
| 60μL | $200.00 |
Product Details
| Abbre | CBL |
| Synonyms | C-CBL, CBL, CBL2, FRA11B, NSLL, RNF55, c-Cbl |
| Swissprot | P22681 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Applications | IHC, IF |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Immunogen | Recombinant fusion protein of human CBL (NP_005179.2). |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction |
| Cellular Localization | Cytoplasm. |
Product Description
Background: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Storage and Shipping
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Additional Information
| Verified Samples | Verified Samples in IHC: Human prostate, Mouse lung Verified Samples in IF: U2OS |
| Dilution | IHC 1:50-1:100, IF 1:50-1:200 |
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