CDKN2A Polyclonal Antibody (E-AB-19334) elabscience
$399.00
In stock
SKU
E-AB-19334
| Size | Price (USD) |
| 200μL | $399.00 |
| 120μL | $240.00 |
| 60μL | $143.00 |
| 20μL | $73.00 |
Product Details
| Abbre | CDKN2A |
| Synonyms | CCM2, CDK4 inhibitor p16 INK4, CDK4I, CDKN2, CDKN2A, CMM2, Cell cycle negative regulator beta, Cyclin Dependent Kinase Inhibitor 2A, Cyclin dependent kinase 4 inhibitor A, Cyclin dependent kinase in, Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4) |
| Swissprot | P42771 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Applications | IHC |
| Conjugation | Unconjugated |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Immunogen | Synthetic peptide of human CDKN2A |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling |
| Cellular Localization | Cytoplasmic and Nuclear. |
Product Description
Background: This gene generates several transcript variants which differ in their first exons.At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase.The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants.This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.
Storage and Shipping
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Additional Information
| Verified Samples | Verified Samples in IHC: Human gastric cancer, Human thyroid cancer |
| Dilution | IHC 1:50-1:200 |
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