C57BL/6JGpt- Hif1a em1Cd4188 /Gpt gempharmatech
$50.00
In stock
SKU
T004662
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Product Summary
| Model | Hif1a-KO |
| Strain Number | T004662 |
| Modification Type | Knockout (KO) |
| Product Type | Cryo Recovery |
Basic Information
| Strain Name | C57BL/6JGpt- Hif1a em1Cd4188 /Gpt |
| Strain Number | T004662 |
| Official Symbol | Hif1a |
| Strain Strategy | T004662.Hif1a Cas9-KO Strategy-EN.pdf (https://en.gempharmatech.com/product/product_details_file:52671) |
| Official Full Name | hypoxia inducible factor 1, alpha subunit |
| Also Known As | AA959795,HIF-1-alpha,HIF1-alpha,HIF1alpha,MOP1,bHLHe78 |
| NCBI Number | 15251 (https://www.ncbi.nlm.nih.gov/gene/15251) |
| MGI Number | 106918 (http://www.informatics.jax.org/marker/MGI:106918) |
| Chromosome | 12 |
| Deletion (size) | -4188bp |
| Research Areas | Metabolic research,Developmental Biology,immune system,integument,cardiovascular system,Tumor research,nervous system,Signal Transduction,skeleton,vision/eye,Muscle ,respiratory system,Cell Proliferation,Cell death,DNA transcription,digestive/alimentary system,Protein metabolism,Glucose metabolism,liver/biliary system,Physiological system,endocrine/exocrine glands,homeostasis/metabolism,behavior/neurological,cell differentiation,Cell biology,Molecular biology,cellular,craniofacial ,embryo,growth/size/body,hematopoietic system,limbs/digits/tail,mortality/aging,Cell localization,cell nucleus,DNA binding protein |
| Strain Background | [N000013] C57BL/6JGpt |
| Modification Type | Knockout (KO) |
| Inventory Status | Cryopreserved |
| Sale Status | IF (Available for Distribution) |
| Health Status | Specific pathogen free (SPF) |
Gene Family
- Basic helix-loop-helix proteins (https://en.gempharmatech.com/product/family_163564.html)
Publications
- HIF-1α mediates mitochondrial damage by down-regulating ALKBH7 expression to promote the aberrant activation of FLS in rheumatoid arthritis. Acta Pharmacol Sin (2025) (https://www.nature.com/articles/s41401-025-01520-y)
- Real-ambient PM2.5 exposure disrupts hematopoietic homeostasis via HIF-1α-driven myeloid skewing and promotes organ inflammation. Particle and fibre toxicology (2025) (https://pmc.ncbi.nlm.nih.gov/articles/PMC12709752/)
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