Recombinant Human CYCS (C-6His)(Cat. No.:CF80) novoprotein
$150.00
In stock
SKU
CF80
10μg: $150
50μg: $440
500μg: $1680
1mg: $2400
Description
Recombinant Human Cytochrome C is produced by our E.coli expression system and the target gene encoding Gly2-Glu105 is expressed with a 6His tag at the C-terminus.
Product Details
| Item | Details |
| Known As | Cytochrome C; CYCS; CYC |
| Mol Mass | 12.8 KDa |
| APMol Mass | 16 KDa, reducing conditions |
| Formulation Description | Supplied as a 0.2 μm filtered solution of 20mM PB, 10% Trehalose, 200mM NaCl, 50% Glycerol, 0.05% Tween 80, pH7.0. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
| Storage | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| Shipping | The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
Background
Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of Cytochrome C to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
title: Low-intensity pulsed ultrasound-generated singlet oxygen induces telomere damage leading to glioma stem cell awakening from quiescence
authors: Sirong Song, Dongbin Ma, Lixia Xu, Qiong Wang, Lanxiang Liu, Xiaoguang Tong, Hua Yan
date: 2021
journal: iScience
title: Combining Whispering-Gallery Mode Optical Biosensors with Microfluidics for Real-Time Detection of Protein Secretion from Living Cells in Complex Media
authors: Ying-Jen Chen, Ulrike Schoeler, Chung-Hsuan (Benjamin) Huang, Frank Vollmer
date: 2018
journal: Small
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