Recombinant Cynomolgus TREM2 (C-6His)(Cat. No.:C15R) novoprotein
$71.00
In stock
SKU
C15R
10μg: $71
50μg: $213
500μg: $1738
1mg: $2600
Description
Recombinant Cynomolgus Triggering receptor expressed on myeloid cells 2 is produced by our Mammalian expression system and the target gene encoding His19-Ser174 is expressed with a 6His tag at the C-terminus.
Product Details
| Item | Details |
| Known As | Ig-like domain-containing protein; TREM2; Triggering receptor expressed on myeloid cells 2 |
| Mol Mass | 18.3 KDa |
| APMol Mass | 28-40 KDa, reducing conditions |
| Formulation Description | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
| Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Storage | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Background
TREM2 is a cell surface receptor of the immunoglobulin superfamily. TREM2 is a type-1 transmembrane protein that shuttles to the plasma membrane where it exerts its cell autonomous biological functions. TREM2 undergoes regulated intramembrane proteolysis (RIP). TREM2 is preferentially expressed in microglia and is functionally required for migration, cytokine release, phagocytosis, lipid sensing, ApoE binding, shielding of amyloid plaques, and microglia proliferation in the brian. Most of the functionally investigated mutations are located within the Ig-like domain of TREM2.
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