Recombinant anti-Human CD16 mAb(Cat. No.:GMP-A091) novoprotein
$50.00
In stock
SKU
GMP-A091
50μg: Inquiry
500μg: Inquiry
1mg: Inquiry
Description
CD16, also known as Fc γ RIII, is an Fc fragment receptor of IgG. It is widely expressed on the surface of NK cells, neutrophil polymorphonuclear leukocytes, mononuclear cells, and macrophages, and is one of the main surface markers of NK cells. CD16 is involved in antibody-dependent cell-mediated cytotoxicity (ADCC) by binding to the Fc of IgG, which in turn activates NK cells. CD16 acts as a low-affinity receptor on the Fc of some IgG to bind to the γ chain of Fc ε-associated receptor I of CD3 ζ (εRI of Fc), thus participating in signal transduction. In addition, CD16 can increase the toxicity of NK cells, upregulate the expression of the genes such as IL-2R, IFN-gamma, and TNF-alpha, increase the secretion of corresponding factors, and serve to activate NK cells and promote proliferation in vitro.
Recombinant Anti-Human CD16 mAb is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.
Usage
In-vitro cultivation of various types of cell.
When Recombinant Anti-Human CD16 mAb is used in combination with IL-2 (Cat. No.: GMP-C013), IL-12 (Cat. No.: GMP-CI58), IL-15 (Cat. No.: GMP-C016), IL-18 (Cat. No.: GMP-CD72), or other cytokines for in vitro NK cell culture, a higher proportion of NK cells and expansion multiples can be achieved.
Product Details
| Item | Details |
| Storage | Storage at -20±5℃, expiration date labeled on bottle. |
Quality Control
| Item | Standard |
| Appearance | Transparent liquid |
| Visible particle | Conform to ChP |
| pH value | 5.0–6.0 |
| Purity | ≥ 95% |
| Bioactivity | ≤10 ng/ml |
| Endotoxin | < 10 EU/mg |
| Host protein | ≤ 0.005% |
| Exogenous DNA residue | ≤ 100 pg/mg |
| Mycoplasma test | Negative |
| Sterility test | Conform to ChP |
Product Details
| Item | Details |
| Recommendations | （1）Make sure the product properly stored and none expired before using. （2）Sterile condition without pyrogen is required for reconstitution, re-aliquoting, dilution. （3）After reconstitution, aliquoted solution vials should be stored at -70°C and minimize freeze-thaw cycles preventing denaturation of protein. |
title: The E3 ubiquitin ligase FBXO38 maintains the antitumor function of natural killer cells by sustaining IL-15R signaling
authors: Shi Yongjing, Zheng Xiaodong, Peng Hui, Xu Chenqi, Sun Rui, Tian Zhigang, Sun Haoyu, Wang Xianwei
date: 2024/07/11
journal: Cancer Immunology Research
MDSD
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