Recombinant Mouse IFN alpha2(Cat. No.:CK83) novoprotein
$122.00
In stock
SKU
CK83
10μg: $122
50μg: $305
500μg: inquiry
1mg: inquiry
Description
Recombinant Mouse Interferon Alpha-2 is produced by our E.coli expression system and the target gene encoding Cys24-Glu190 is expressed.
Product Details
| Item | Details |
| Known As | Interferon Alpha-2; IFN-Alpha-2; Interferon Alpha-A; LeIF A; IFNA2 |
| Mol Mass | 19.5 KDa |
| APMol Mass | 16 KDa, reducing conditions |
| Formulation Description | Lyophilized from a 0.2 μm filtered solution of 20mM Histidine-HCl, 6% Sucrose, 4% Mannitol, 0.02% Tween80 (w/v), pH 6.0. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
| Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Storage | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Background
At least 23 different variants of Interferon-α are known. The individual proteins have molecular masses between 19-26 kD and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-α subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-α subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxyl-terminal end.
title: Interferon α-induced HERC6 provokes podocyte dysfunction via mitotic catastrophe in lupus nephritis
authors: Wei Xiaoquan, Wang Shuhui, Peng Wenkun, Hang Yang, Yang Qianyue, Sun Shuning, Meng Defang, Nie Min, Yao Genhong, Sun Lingyun
date: 2026/04/22
journal: ARTHRITIS RESEARCH & THERAPY
title: Immunotherapy Inhibits Tumor Cholesterol Synthesis via the IFN-γ-ΙRF1-SREBF2 Axis
authors: Xu Liping, Zhang Xiaomin, Lai Xiaowei, Chen Hongyuan, Liao Shuangye, Chang Mingzeng, Wu Xiaoqing, Rui Wen, Yang Juan, Wang Danyang, Gao Chengqi, Fang Ziqian, Zhang Jianeng, Li Wende, Li Bo, Xia Xiaojun, Zhou Penghui
date: 2025/12/09
journal: Cancer Immunology Research
title: RORγt agonist LYC-55716 potentiates IFN-α’s efficacy in hepatocellular carcinoma through enhancing cytotoxicity of Tc17 cells and infiltration of CD8+ T cells
authors: Heng Wang, Guojiang Zhang, Cai Zhao, Youan Xue, Di Zhu, Yan Chang
date: 2025/04/29
journal: BIOCHEMICAL PHARMACOLOGY
title: Upregulation of RIG-I is Critical for Responsiveness to IFN-α Plus Anti-PD-1 in Colorectal Cancer
authors: Haihang Nie, Shilin Fang, Rui Zhou, Yifan Jia, Jingkai Zhou, Yumei Ning, Yali Yu, Yuntian Hong, Fei Xu, Qiu Zhao, Jiayan Nie, Fan Wang
date: 2025/03/21
journal: Cancer Medicine
title: Pbx3-mediated suppression of type I interferon response contributes to leukemia progression driven by MLL-AF9
authors: Tang Li, Lu Meng, Du Yulong, Sun Jianlong
date: 2025/03/19
journal: CANCER GENE THERAPY
title: GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development
authors: Fan Zhao, Zejin Cui, Pengfei Wang, Zhishan Zhao, Kaixiang Zhu, Yadan Bai, Xuexiao Jin, Lie Wang, Linrong Lu
date: 2024/07/08
journal: DEVELOPMENTAL CELL
title: Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses
authors: Bin Qian, Rui Lu, Shuya Mao, Yang Chen, Miao Yang, Wenxuan Zhang, Mingchao Zhang, Dihan Zhu, Zhihong Liu, Ke Zen, Limin Li
date: 2024/05/16
journal: Cell Reports
title: Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21
authors: Yu-Yao Guo, Yue Gao, Yun-Lin Zhao, Chang Xie, Hu Gan, Xufeng Cheng, Li-Ping Yang, Junyan Hu, Hong-Bing Shu, Bo Zhong, Dandan Lin, Jing Yao
date: 2024/04/12
journal: Cell Reports
title: Deacetylase Sirtuin 1 mitigates type I IFN- and type II IFN-induced signaling and antiviral immunity
authors: Shuang-Shuang Yu, Rong-Chun Tang, Ao Zhang, Shijin Geng, Hengxiang Yu, Yan Zhang, Xiu-Yuan Sun, Jun Zhang
date: 2024/02/22
journal: JOURNAL OF VIROLOGY
title: Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
authors: Xianghui Kong, Xinliang Lu, Shibo Wang, Jiayue Hao, Danfeng Guo, Hao Wu, Yu Jiang, Yi Sun, Jianli Wang, Gensheng Zhang, Zhijian Cai
date: 2023
journal: Cell Reports
title: Critical role of interferons in gastrointestinal injury repair
authors: McElrath Constance, Espinosa Vanessa, Lin Jian-Da, Peng Jianya, Sridhar Raghavendra, Dutta Orchi, Tseng Hsiang-Chi, Smirnov Sergey V., Risman Heidi, Sandoval Marvin J., Davra Viralkumar, Chang Yun-Juan, Pollack Brian P., Birge Raymond B., Galan Mark, Rivera Amariliz, Durbin Joan E., Kotenko Sergei V.
date: 2021
journal: Nature Communications
title: Si-Ni-San ameliorates chronic colitis by modulating type I interferons-mediated inflammation
authors: Yajie Cai, Bing Xu, Fei Zhou, Jianzhi Wu, Shuo Li, Qi Zheng, Yajing Li, Xiaojiaoyang Li, Feng Gao, Shifen Dong, Runping Liu
date: 2021
journal: PHYTOMEDICINE
title: Type I Interferon Signaling Is a Common Factor Driving Streptococcus pneumoniae and Influenza A Virus Shedding and Transmission | mBio
authors: Tonia Zangari, Mila B. Ortigoza, Kristen L. Lokken-Toyli, Jeffrey N. Weiser
date: 2021
journal: mBio
title: Dectin-1 Promotes Type I and III Interferon Expression to Support Optimal Antifungal Immunity in the Lung
authors: Dutta Orchi, Espinosa Vanessa, Wang Keyi, Avina Samantha, Rivera Amariliz
date: 2020
journal: Frontiers in Cellular and Infection Microbiology
title: Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a–LCOR axis
authors: Celià-Terrassa Toni, Liu Daniel D., Choudhury Abrar, Hang Xiang, Wei Yong, Zamalloa Jose, Alfaro-Aco Raymundo, Chakrabarti Rumela, Jiang Yi-Zhou, Koh Bong Ihn, Smith Heath A., DeCoste Christina, Li Jun-Jing, Shao Zhi-Ming, Kang Yibin
date: 2017
journal: NATURE CELL BIOLOGY
title: Type III interferon is a critical regulator of innate antifungal immunity
authors: Vanessa Espinosa, Orchi Dutta, Constance McElrath, Peicheng Du, Yun-Juan Chang, Bryan Cicciarelli, Amy Pitler, Ian Whitehead, Joshua J. Obar, Joan E. Durbin, Sergei V. Kotenko, Amariliz Rivera
date: 2017
journal: Science Immunology
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