Recombinant Human GPC3 (C-Fc)(Cat. No.:CW66) novoprotein
$60.00
In stock
SKU
CW66
10μg: $60
50μg: $181
500μg: $1484
1mg: $2225
Description
Recombinant Human Glypican-3 is produced by our Mammalian expression system and the target gene encoding Gln25-His559 is expressed with a human IgG1 Fc tag at the C-terminus.
Product Details
| Item | Details |
| Known As | Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5 |
| Mol Mass | 87.7 KDa |
| APMol Mass | 40 KDa & 65 KDa & 90-250 KDa, reducing conditions |
| Formulation Description | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
| Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Storage | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Background
Glypican-3/GPC3 is a member of the glypican family. It belongs to the glypican family and is highly expressed in lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.
title: Organ-specific delivery of an mRNA-encoded bispecific T cell engager targeting glypican-3 in hepatocellular carcinoma
authors: Huang Yan, Liu Shaoli, Zhang Xiaoju, Zhang Bingxu, Shi Feng, Zhang Jia, Shao Shuaibo, Han Hongya, Ma Xiaoyun, Xie Jing, Zhang Jianqi, Yu Hongxiaoying, Zhao Yongchao, Jin Jiazheng, Xu Dong, Liu Liang, Wang Jianing, Tan Yu, Xu Kelu, Jin Lushuai, Du Quanjun, Geng Yifeng, Liu Andong, Xu Wei
date: 2025/12/15
journal: Nature Communications
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