CoraLite® Plus 405 Anti-Mouse CD41 (MWReg30) CL405-65189 proteintech
$172.00
In stock
SKU
CL405-65189
| Catalog Number | CL405-65189 |
| Synonyms | Itga2b, GpIIb, integrin alpha 2b, MWReg30 |
| Host | Rat |
| Reactivity | mouse |
| Form | Liquid |
| Formulation | PBS, Azide |
| Applications | FC |
| Host / Isotype | Rat / IgG1, kappa |
| Tested Applications — Positive FC detected in | mouse peripheral blood platelets, mouse splenocytes |
| Positive FC detected in | mouse peripheral blood platelets, mouse splenocytes |
| Flow Cytometry (FC) | FC : 0.5 ug per 10^6 cells in 100 μl suspension |
| Tested Reactivity | mouse |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | Mouse platelets Predict reactive species |
| Full Name | integrin alpha 2b |
| GenBank Accession Number | BC120493 |
| Gene Symbol | CD41 |
| Gene ID (NCBI) | 16399 |
| RRID | AB_3083839 |
| Conjugate | CoraLite® Plus 405 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 399 nm / 422 nm |
| Excitation Laser | Violet Laser (405 nm) |
| Purification Method | Affinity purification |
| UNIPROT ID | Q9QUM0 |
| Storage Buffer | PBS with 0.09% sodium azide, pH 7.3. |
| Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
| FC protocol for CL Plus 405 CD41 antibody CL405-65189 | Download protocol |
| Citations | - |
| Isotype | IgG1, kappa |
| Clonality | Monoclonal |
| Clone Number | MWReg30 |
| Conjugation | CoraLite® Plus 405 |
The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID: 19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light beta (25 kDa) and heavy alpha (125 kDa) chains, which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. CD41/CD61 is crucial for platelet aggregation through binding of soluble fibrinogen. Protocols Product Specific Protocols FC protocol for CL Plus 405 CD41 antibody CL405-65189 Download protocol Standard Protocols Click here to view our Standard Protocols
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