CA8 Recombinant monoclonal antibody, PBS Only 86004-1-PBS proteintech
$699.00
In stock
SKU
86004-1-PBS
| Catalog Number | 86004-1-PBS |
| Synonyms | carbonic anhydrase VIII, CA 8, CA VIII, CALS, Carbonic anhydrase-related protein |
| Host | Rabbit |
| Reactivity | human, mouse |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | IHC, IF-P, Indirect ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Reactivity | human, mouse |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | CatNo: Ag3068 Product name: Recombinant human CA8 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-143 aa of BC015531 Sequence: MADLSFIEDTVAFPEKEEDEEEEEEGVEWGYEEGVEWGLVFPDANGEYQSPINLNSREARYDPSLLDVRLSPNYVVCRDCEVTNDGHTIQVILKSKSVLSGGPLPQGHEFELYEVRFHWGRENQRGSEHTVNFKAFPMEVRIT Predict reactive species |
| Full Name | carbonic anhydrase VIII |
| Calculated Molecular Weight | 290 aa, 32 kDa |
| GenBank Accession Number | BC015531 |
| Gene Symbol | CA8 |
| Gene ID (NCBI) | 767 |
| RRID | AB_3744541 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | P35219 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
| Citations | - |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 250429B8 |
| Conjugation | Unconjugated |
The CA8 (CARP) gene encodes carbonic anhydrase VIII, which is part of a family of zinc metalloenzyme. CA8 has a central carbonic anhydrase motif, but it lacks carbonic anhydrase activity due to absence of catalytic zinc coordinating residues(PMID:2121526). CARP is a novel IP3R1-binding protein, and is expressed in Purkinje cells abundantly. CA8 is co-localized with IP3R1 in Purkinje cells and it binds to IP3R1, reducing the affinity of the receptor for its ligand, IP3(PMID:12611586). Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3)(PMID:19461874).
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