Anti-Human CD163 (GHI/61) Mouse IgG2a Recombinant Antibody, PBS Only 65561-1-PBS proteintech
$560.00
In stock
SKU
65561-1-PBS
| Catalog Number | 65561-1-PBS |
| Synonyms | CD163 molecule, GHI/61, Hemoglobin scavenger receptor, M130, MM130 |
| Host | Mouse |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | FC |
| Host / Isotype | Mouse / IgG2a |
| Tested Reactivity | human |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Glycoprotein preparation from hairy cell leukemia spleen Predict reactive species |
| Full Name | CD163 molecule |
| Calculated Molecular Weight | 1156 aa, 125 kDa |
| GenBank Accession Number | BC051281 |
| Gene Symbol | CD163 |
| Gene ID (NCBI) | 9332 |
| ENSEMBL Gene ID | ENSG00000177575 |
| RRID | AB_3670315 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purfication |
| UNIPROT ID | Q86VB7 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. Stable for one year after shipment. |
| Citations | - |
| Isotype | IgG2a |
| Clonality | Recombinant |
| Clone Number | GHI/61 |
| Conjugation | Unconjugated |
CD163, also known as M130, is a membrane glycoprotein that belongs to the scavenger receptor superfamily (PMID: 8370408). It is an acute phase-regulated and signal-inducing macrophage protein expressed exclusively in monocytes and tissue macrophages (PMID: 11196644). CD163 mediates endocytosis of haptoglobin-haemoglobin complexes (PMID: 11196644). The uptake of haptoglobin by macrophages contributes to the recycling of iron and also to the inflammatory response (PMID: 22900885). Soluble CD163 (sCD163), as a result of ectodomain shedding during inflammatory activation of macrophages, circulates in blood and has been suggested as a plasma/serum marker for macrophage activity (PMID: 12570164).
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