HO-1/HMOX1 Monoclonal antibody 66743-1-Ig proteintech
$149.00
In stock
SKU
66743-1-Ig
| Catalog Number | 66743-1-Ig |
| Synonyms | HMOX1, HO-1, 2D10A5, bK286B10, EC:1.14.14.18 |
| Host | Mouse |
| Reactivity | human, mouse, rat, pig, rabbit and More (2) |
| Reactivity | human, mouse, rat, pig, rabbit, hamster, sheep |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, IF-P, FC (Intra), IP, CoIP, ELISA |
| Applications | WB, IHC, IF-P, FC (Intra), ELISA |
| Host / Isotype | Mouse / IgG2a |
| Tested Applications — Positive WB detected in | HEK-293 cells, A549 cells, pig spleen tissue, HepG2 cells, HeLa cells, HSC-T6 cells, rat liver tissue, rat spleen tissue, pig liver tissue, rabbit liver tissue |
| Tested Applications — Positive IHC detected in | human liver cancer tissue, human renal cell carcinoma tissue, human kidney tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Tested Applications — Positive IF-P detected in | mouse spleen tissue, rat liver tissue |
| Tested Applications — Positive FC (Intra) detected in | HeLa cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:1000-1:6000 |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:500-1:2000 |
| Recommended Dilutions — Immunofluorescence (IF)-P | IF-P : 1:200-1:800 |
| Recommended Dilutions — Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension |
| Positive WB detected in | HEK-293 cells, A549 cells, pig spleen tissue, HepG2 cells, HeLa cells, HSC-T6 cells, rat liver tissue, rat spleen tissue, pig liver tissue, rabbit liver tissue |
| Positive IHC detected in | human liver cancer tissue, human renal cell carcinoma tissue, human kidney tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse spleen tissue, rat liver tissue |
| Positive FC (Intra) detected in | HeLa cells |
| Western Blot (WB) | WB : 1:1000-1:6000 |
| Immunohistochemistry (IHC) | IHC : 1:500-1:2000 |
| Immunofluorescence (IF)-P | IF-P : 1:200-1:800 |
| Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension |
| Tested Reactivity | human, mouse, rat, pig, rabbit |
| Cited Reactivity | human, mouse, rat, pig, rabbit, hamster, sheep |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag21296 Product name: Recombinant human HO-1 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-288 aa of BC001491 Sequence: MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQHYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM Predict reactive species |
| Full Name | heme oxygenase (decycling) 1 |
| Calculated Molecular Weight | 33 kDa |
| Observed Molecular Weight | 33 kDa |
| GenBank Accession Number | BC001491 |
| Gene Symbol | HO-1 |
| Gene ID (NCBI) | 3162 |
| RRID | AB_2882091 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | P09601 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| FC protocol for HO-1/HMOX1 antibody 66743-1-Ig | Download protocol |
| IF protocol for HO-1/HMOX1 antibody 66743-1-Ig | Download protocol |
| IHC protocol for HO-1/HMOX1 antibody 66743-1-Ig | Download protocol |
| WB protocol for HO-1/HMOX1 antibody 66743-1-Ig | Download protocol |
| mouse | WB Biomaterials MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system. Authors - Tian Wang View Article |
| human | WB,IF J Nanobiotechnology Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis Authors - Ningning Yue View Article |
| Marina (Verified Customer) (07-24-2024) | great antibody. Incubation with primary antibody (1:3000) ON at 4C. Incubation with secondary antibody (mouse) at RT for 2h. Applications: Western Blot Primary Antibody Dilution: 1:1000 Cell Tissue Type: Human cell lines HO-1/HMOX1 Antibody Western Blot validation (1:1000 dilution) in Human cell lines (Cat no:66743-1-Ig) |
| Brice-Emmanuel (Verified Customer) (12-18-2023) | Does not work. Non-specific band at 70 kDa Applications: Western Blot Primary Antibody Dilution: 1/1000 Cell Tissue Type: Mouse Heart Tissue HO-1/HMOX1 Antibody Western Blot validation (1/1000 dilution) in Mouse Heart Tissue (Cat no:66743-1-Ig) |
| Ayse Tarbin (Verified Customer) (03-16-2023) | It was a gift antibody. It worked perfectly after 2h incubation at room temp. Definately I will consider to buy it. Applications: Western Blot, Cell culture Primary Antibody Dilution: 1:2000 in 5% milk in TBST Cell Tissue Type: Mouse satellite cells HO-1/HMOX1 Antibody Western Blot,Cell culture validation (1:2000 in 5% milk in TBST dilution) in Mouse satellite cells (Cat no:66743-1-Ig) |
| Hala (Verified Customer) (08-17-2021) | HO-1 expression was revealed with a donkey anti-mouse 547 red secondary antibody Applications: Immunofluorescence Primary Antibody Dilution: 1/100 Cell Tissue Type: hepG2 HO-1/HMOX1 Antibody Immunofluorescence validation (1/100 dilution) in hepG2 (Cat no:66743-1-Ig) |
| Marta (Verified Customer) (09-29-2020) | Western blotting of Hmox1 in mouse liver. Used at a 1:1000 dilution in 3% milk and TBST overnight at 4 degrees. Applications: Western Blot Primary Antibody Dilution: 1:1000 Cell Tissue Type: Mouse liver HO-1/HMOX1 Antibody Western Blot validation (1:1000 dilution) in Mouse liver (Cat no:66743-1-Ig) |
| Citations | 264 |
| Dilutions | WB : 1:1000-1:6000 IHC : 1:500-1:2000 IF-P : 1:200-1:800 FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Clone Number | 2D10A5 |
| Conjugation | Unconjugated |
Heme oxygenase (HMOX1) catalyzes the first and rate-limiting step in the degradation of heme to yield equimolar quantities of biliverdin Ixa, carbon monoxide (CO), and iron. It has 3 isoforms: HO-1 is highly inducible, whereas HO-2 and HO-3 are constitutively expressed (PMID:10194478). Heme oxygenase-1 (HO-1) is expressed in many tissues and vascular smooth muscle cells, and endothelial cells (PMID:15451051) and has been identified as an important endogenous protective factor induced in many cell types by various stimulants, such as hemolysis, infiammatory cytokines,oxidative stress, heat shock, heavy metals, and endotoxin (PMID: 11522663). And the full-length HO-1 is very unstable and susceptible to truncation that generates an inactive, soluble form (28 kDa) (James R. Reed, Pharmacology, 535-568). Protocols Product Specific Protocols FC protocol for HO-1/HMOX1 antibody 66743-1-Ig Download protocol IF protocol for HO-1/HMOX1 antibody 66743-1-Ig Download protocol IHC protocol for HO-1/HMOX1 antibody 66743-1-Ig Download protocol WB protocol for HO-1/HMOX1 antibody 66743-1-Ig Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3-Regulated HIF1A/HMOX1 Signaling Pathway
Journal: Adv Sci (Weinh) | Authors: Zongwen Liang | Application: WB,IHC - Polymer-Encapsulated Catalase for Targeted Redox Regulation in Acute Liver Injury
Journal: Small | Authors: Feifei Li | Species: mouse | Application: WB - HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis
Journal: Dev Cell | Authors: Xiang Peng | Species: human - Bioinspired Multifunctional Black Phosphorus Hydrogel with Antibacterial and Antioxidant Properties: A Stepwise Countermeasure for Diabetic Skin Wound Healing.
Journal: Adv Healthc Mater | Authors: Qiuyue Ding | Application: WB - MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.
Journal: Biomaterials | Authors: Tian Wang | Species: mouse | Application: WB - Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis
Journal: J Nanobiotechnology | Authors: Ningning Yue | Species: human | Application: WB,IF - A First-Aid Nanomedicine Endowed with Microenvironment Self-Adaptive Regulation Ability to Facilitate Acute Liver Failure Prophylaxis and Therapy.
Journal: ACS Nano | Authors: Jiale Zhang - Adaptive bilirubin nanoscavenger alleviates pulmonary oxidative stress and inflammation for acute lung injury therapy
Journal: J Adv Res | Authors: Longfa Kou | Species: human | Application: WB - High-throughput screening identifies FDA approved drug mitiglinide as a novel pyroptosis inhibitor and therapeutic agent for osteoarthritis.
Journal: J Adv Res | Authors: Hanwen Zhang | Species: mouse | Application: WB - Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO-1 signaling pathway
Journal: Redox Biol | Authors: Guoda Song | Species: rat | Application: WB - Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes
Journal: Redox Biol | Authors: Weijun Huang | Species: mouse,human | Application: IF - Celastrol nanomedicine eye drops restore redox homeostasis and prevents keratoconus progression via PI3K/AKT/AP-1 signaling.
Journal: Redox Biol | Authors: Ruixing Liu | Species: human,rabbit | Application: WB,IHC,IF - Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis
Journal: J Nanobiotechnology | Authors: Ningning Yue | Species: human | Application: WB,IF - Targeting CH25H/25HC-ferroptosis axis: a novel mechanism of MSC-EVs mediated renoprotection in ischemic AKI.
Journal: J Nanobiotechnology | Authors: Qin Yang - Ultrasound targeted microbubble destruction assisted exosomal delivery of siHmox1 effectively inhibits doxorubicin-induced cardiomyocyte ferroptosis
Journal: J Nanobiotechnology | Authors: Jianmei Chen | Species: mouse | Application: WB - Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles.
Journal: J Nanobiotechnology | Authors: Na Li | Species: mouse,human | Application: WB - GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation
Journal: Theranostics | Authors: Yanfei Cheng | Species: human | Application: WB - TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling
Journal: J Exp Clin Cancer Res | Authors: Teng Xu | Species: mouse,human | Application: WB,IHC - Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple-Negative Breast Cancer
Journal: Adv Sci (Weinh) | Authors: Tong Yang | Species: human,mouse | Application: WB,IHC - PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma
Journal: Adv Sci (Weinh) | Authors: Jitong Zhou | Species: human | Application: WB - Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3-Regulated HIF1A/HMOX1 Signaling Pathway
Journal: Adv Sci (Weinh) | Authors: Zongwen Liang | Application: WB,IHC - A Bioinspired Manganese-Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant Enzymes
Journal: Adv Sci (Weinh) | Authors: Jian Wang | Species: mouse | Application: WB - Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis
Journal: Cell Rep Med | Authors: Xuqing Shen | Species: mouse | Application: WB - An ATPase-Mimicking MXene nanozyme pharmacologically breaks the ironclad defense system for ferroptosis cancer therapy
Journal: Biomaterials | Authors: Huan Wang | Species: human | Application: WB - MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.
Journal: Biomaterials | Authors: Tian Wang | Species: mouse | Application: WB - Bletilla striata polysaccharide protects against UVA-induced skin damage by activating Nrf2/HO-1 signaling and inhibiting ferroptosis.
Journal: Carbohydr Polym | Authors: Mei Wang | Species: human | Application: WB - Immune-epithelial dual-targeting bilirubin nanoparticles for acute lung injury.
Journal: J Control Release | Authors: Yingying Tang | Species: mouse, human | Application: WB,IHC,IF - A dual Keap1 and p47phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis
Journal: Cell Death Dis | Authors: Zi-Chao Wang | Species: human | Application: WB - Ammonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells
Journal: Cell Death Dis | Authors: Mengling Zhang | Species: human | Application: WB - TBHQ attenuates ferroptosis against 5-fluorouracil-induced intestinal epithelial cell injury and intestinal mucositis via activation of Nrf2.
Journal: Cell Mol Biol Lett | Authors: Shihua Deng | Species: mouse | Application: WB - A dual Keap1 and p47phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis
Journal: Cell Death Dis | Authors: Zi-Chao Wang | Species: human | Application: WB - Polymer-Encapsulated Catalase for Targeted Redox Regulation in Acute Liver Injury
Journal: Small | Authors: Feifei Li | Species: mouse | Application: WB - Multifunctional Silk Fibroin Methacryloyl Microneedle for Diabetic Wound Healing
Journal: Small | Authors: Gaopeng Guan | Species: mouse | Application: WB,IF - Anti-tumor effects of Cinnamomum camphora essential oil in breast cancer via NOX4 modulation by (+)-2-bornanone
Journal: Phytomedicine | Authors: Ruzhen Zheng - Polyphyllin I induced ferroptosis to suppress the progression of hepatocellular carcinoma through activation of the mitochondrial dysfunction via Nrf2/HO-1/GPX4 axis
Journal: Phytomedicine | Authors: Renyi Yang | Species: mouse,human | Application: WB,IF - Lanatoside C inhibits herpes simplex virus 1 replication by regulating NRF2 distribution within cells
Journal: Phytomedicine | Authors: Songbin Wu | Application: WB - Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways.
Journal: Phytomedicine | Authors: Yifeng Shi | Species: mouse | Application: WB - Ginsenoside Rh2 and luteolin synergistically induce cellular senescence to suppress hepatocellular carcinoma progression through oxidative stress-mediated mechanisms.
Journal: Phytomedicine | Authors: Jieya Huang - Centipeda minima extract exhibits anti-liver cancer effects via the ER stress/HMOX1/Fe2+/ROS pathway
Journal: Phytomedicine | Authors: Jinrui Wei | Species: human | Application: WB - Fangchinoline suppresses hepatocellular carcinoma by regulating ROS accumulation via the TRIM7/Nrf2 signaling pathway
Journal: Phytomedicine | Authors: Yange Liu | Species: human | Application: WB - Arnicolide C induces ferroptosis in liver cancer through modulation of the HMOX1-TRC8 axis.
Journal: Phytomedicine | Authors: Xuqi Zhao - Sinomenine inhibits oxidative stress to attenuate Alzheimer's disease pathology via α7 nicotinic acetylcholine receptor.
Journal: Phytomedicine | Authors: Haojie Ni - Anti-tumor effects of Cinnamomum camphora essential oil in breast cancer via NOX4 modulation by (+)-2-bornanone
Journal: Phytomedicine | Authors: Ruzhen Zheng - Atractylenolide III alleviates cerebral ischemia-reperfusion injury by targeting Keap1 to activate the Nrf2/HO-1 pathway
Journal: Phytomedicine | Authors: Roujia Guo | Application: WB - Bioinspired Multifunctional Black Phosphorus Hydrogel with Antibacterial and Antioxidant Properties: A Stepwise Countermeasure for Diabetic Skin Wound Healing.
Journal: Adv Healthc Mater | Authors: Qiuyue Ding | Application: WB - A Biomimetic Nanoparticle Exerting Protection Against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS
Journal: Adv Healthc Mater | Authors: Qing Yao | Species: mouse | Application: WB - Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1.
Journal: Acta Pharmacol Sin | Authors: Jia-Wei Li | Species: human | Application: WB - CZ-7, a new derivative of Claulansine F, ameliorates 2VO-induced vascular dementia in rats through a Nrf2-mediated antioxidant responses.
Journal: Acta Pharmacol Sin | Authors: Dan-Dan Liu | Species: rat | Application: WB - Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1.
Journal: Cell Death Discov | Authors: Shishi Li | Species: mouse | Application: IF - Severe hyperoxia during VA-ECMO promotes oxidative stress and multi-organ injury in an experimental rat model of septic cardiomyopathy.
Journal: J Transl Med | Authors: Tianlong Wang - Volvariella volvacea polysaccharides alleviate acute liver injury by modulating Nrf2/NF-κB pathway in a dual manner.
Journal: NPJ Sci Food | Authors: Xiaomin Li | Species: mouse | Application: WB,IHC - HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis
Journal: Dev Cell | Authors: Xiang Peng | Species: human - The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1.
Journal: Oncogene | Authors: Ming Gao | Species: human | Application: WB,IP,IHC - Machine learning-driven screening of antioxidant peptides from macadamia nuts: In vitro experimental validation and mechanistic insights.
Journal: Food Res Int | Authors: Weiye Jiang | Species: human | Application: WB - Amelioration of obesity-induced endothelial dysfunction by a synthetic ocean-derived peptide via regulating PPARα/γ pathway.
Journal: Food Res Int | Authors: Xinyi Chen | Species: mouse, rat | Application: WB - Machine learning-driven screening of antioxidant peptides from macadamia nuts: In vitro experimental validation and mechanistic insights.
Journal: Food Res Int | Authors: Weiye Jiang | Species: human | Application: WB - Structural characterization, anti-aging activity and mechanisms investigation in vivo of a polysaccharide from Anthriscus sylvestris
Journal: Int J Biol Macromol | Authors: Xiaoyun Ji | Species: mouse | Application: WB - Neuroprotective effects of Lycium barbarum polysaccharide on light-induced oxidative stress and mitochondrial damage via the Nrf2/HO-1 pathway in mouse hippocampal neurons
Journal: Int J Biol Macromol | Authors: Yang Yang | Species: mouse | Application: WB - Structural characterization and multi-omics analysis of novel Saposhnikovia divaricata (Turcz.) Schischk acidic heteropolysaccharide alleviating acute liver injury.
Journal: Int J Biol Macromol | Authors: Xialin Sun | Species: mouse | Application: WB - Study on the Local Anti-Osteoporosis Effect of Polaprezinc-Loaded Antioxidant Electrospun Membrane
Journal: Int J Nanomedicine | Authors: Xue Gao | Species: mouse | Application: WB - Polysaccharide from Flammulina velutipes residues protects mice from Pb poisoning by activating Akt/GSK3β/Nrf-2/HO-1 signaling pathway and modulating gut microbiota
Journal: Int J Biol Macromol | Authors: Yingying Liu | Species: mouse | Application: WB - Study on the Local Anti-Osteoporosis Effect of Polaprezinc-Loaded Antioxidant Electrospun Membrane
Journal: Int J Nanomedicine | Authors: Xue Gao | Species: mouse | Application: WB - Treatment of radiation-induced brain injury with bisdemethoxycurcumin.
Journal: Neural Regen Res | Authors: Shuang-Xi Chen | Species: rat | Application: WB - Dihydromyricetin Enhances Intestinal Antioxidant Capacity of Growing-Finishing Pigs by Activating ERK/Nrf2/HO-1 Signaling Pathway.
Journal: Antioxidants (Basel) | Authors: Chuan Wei | Species: pig | Application: WB - Cardiac NF-κB Acetylation Increases While Nrf2-Related Gene Expression and Mitochondrial Activity Are Impaired during the Progression of Diabetes in UCD-T2DM Rats.
Journal: Antioxidants (Basel) | Authors: Max A Thorwald | Species: rat | Application: WB - Transfer of Antioxidant Capacity Through Placenta and Colostrum: β-Carotene and Superoxide Dismutase Collaboratively Enhance Integrated Breeding of Sows and Piglets
Journal: Antioxidants (Basel) | Authors: Jun Huang | Species: pig | Application: WB - Transfer of Antioxidant Capacity Through Placenta and Colostrum: β-Carotene and Superoxide Dismutase Collaboratively Enhance Integrated Breeding of Sows and Piglets
Journal: Antioxidants (Basel) | Authors: Jun Huang | Species: pig | Application: WB - Dihydromyricetin Enhances Intestinal Antioxidant Capacity of Growing-Finishing Pigs by Activating ERK/Nrf2/HO-1 Signaling Pathway.
Journal: Antioxidants (Basel) | Authors: Chuan Wei | Species: pig | Application: WB - Baicalin ameliorates high fat diet-induced nonalcoholic fatty liver disease in mice via adenosine monophosphate-activated protein kinase-mediated regulation of SREBP1/Nrf2/NF-κB signaling pathways
Journal: Phytother Res | Authors: Yanxia Gao | Species: mouse | Application: WB - Curcumin Alleviates the Osteogenesis Inhibition and the Aging Process in BMSCs Induced by Iron Overload Through Activating the NRF2/GPX4 Pathway.
Journal: Phytother Res | Authors: Jingmin Che | Species: mouse | Application: WB - Heme-mediated liver-heart axis promotes myocardial pyroptosis in db/db mice.
Journal: Free Radic Biol Med | Authors: Jiaxin Gu - Ginkgolide B-loaded detachable microneedles attenuate androgenetic alopecia by suppressing endoplasmic reticulum stress via the Nrf2/HO-1 pathway.
Journal: Free Radic Biol Med | Authors: Zhan Wang - Heme-mediated liver-heart axis promotes myocardial pyroptosis in db/db mice.
Journal: Free Radic Biol Med | Authors: Jiaxin Gu - Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide-releasing tricarbonyldichlororuthenium (II) dimer.
Journal: Free Radic Biol Med | Authors: Katarzyna Magierowska | Species: rat | Application: IHC - Ginkgolide B-loaded detachable microneedles attenuate androgenetic alopecia by suppressing endoplasmic reticulum stress via the Nrf2/HO-1 pathway.
Journal: Free Radic Biol Med | Authors: Zhan Wang - Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages
Journal: Free Radic Biol Med | Authors: Wei Yu | Species: human | Application: WB - Restoring BECN1-mediated autophagy mitigates acute lung injury caused by zinc oxide nanoparticles.
Journal: Free Radic Biol Med | Authors: Lejiao Mao - Targeting PTGDS Promotes ferroptosis in peripheral T cell lymphoma through regulating HMOX1-mediated iron metabolism
Journal: Br J Cancer | Authors: Shunfeng Hu | Species: human | Application: WB,IF,CoIP - Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy
Journal: Stem Cell Res Ther | Authors: Ying Wang | Species: rat | Application: WB - NIR-Mediated Pyroelectric Catalysis for Sustained ROS/RNS Generation and Advanced Cancer Therapy In Vivo via Injectable Hydrogel
Journal: ACS Appl Mater Interfaces | Authors: Yandai Lin | Species: human | Application: WB - Targeting PTGDS Promotes ferroptosis in peripheral T cell lymphoma through regulating HMOX1-mediated iron metabolism
Journal: Br J Cancer | Authors: Shunfeng Hu | Species: human | Application: WB,IF,CoIP - Nanovesicles Synergistically Regulate Ferroptosis Characteristic Macrophage-Induced Angiogenesis via Ferritin Heavy Chain 1/Glutathione Peroxidase 4 Pathway to Promote Peripheral Nerve Regeneration.
Journal: ACS Appl Mater Interfaces | Authors: Nianci Huo | Species: human, mouse, rat | Application: IHC,IF - Mesenchymal stem cells improve redox homeostasis and mitochondrial respiration in fibroblast cell lines with pathogenic MT-ND3 and MT-ND6 variants.
Journal: Stem Cell Res Ther | Authors: Tharsini Navaratnarajah | Species: human | Application: WB - Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway
Journal: World J Gastroenterol | Authors: Kai-Di Chen | Species: rat | Application: WB,IHC - miR-140-5p Overexpression Contributes to Oxidative Stress and Mitochondrial Dysfunction in Hutchinson-Gilford Progeria Syndrome Fibroblasts Through NRF2 Pathway.
Journal: Aging Cell | Authors: Léa Toury | Species: human | Application: WB - Methyleugenol alleviates pulmonary vascular remodeling in rats with high-altitude pulmonary hypertension by improving pulmonary smooth muscle cell function
Journal: Biomed Pharmacother | Authors: Yang Yu | Species: rat | Application: WB - Myeloid-specific deficiency of group VIA calcium-independent phospholipase A2 preconditions myeloid cells for injury resolution after acetaminophen exposure
Journal: Biomed Pharmacother | Authors: Feng Xu | Species: mouse | Application: WB - Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis
Journal: Chin Med | Authors: Ruizhi Wang | Species: human | Application: WB - PPARγ Alleviates Sepsis-Induced Liver Injury by Inhibiting Hepatocyte Pyroptosis via Inhibition of the ROS/TXNIP/NLRP3 Signaling Pathway.
Journal: Oxid Med Cell Longev | Authors: Zeyu Li | Species: mouse | Application: WB - Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK.
Journal: Oxid Med Cell Longev | Authors: Ning Ma | Species: human | Application: WB - PPARγ Alleviates Sepsis-Induced Liver Injury by Inhibiting Hepatocyte Pyroptosis via Inhibition of the ROS/TXNIP/NLRP3 Signaling Pathway.
Journal: Oxid Med Cell Longev | Authors: Zeyu Li | Species: mouse | Application: WB - Peptides Isolated from Yak Milk Residue Exert Antioxidant Effects through Nrf2 Signal Pathway.
Journal: Oxid Med Cell Longev | Authors: Feiyan Yang | Species: human | Application: WB - Limonin Inhibits IL-1 β -Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2
Journal: Oxid Med Cell Longev | Authors: Jie Jin | Species: mouse | Application: WB,IHC - The clustering status of detached gastric cancer cells inhibits anoikis-induced ferroptosis to promote metastatic colonization
Journal: Cancer Cell Int | Authors: Juan Sun | Species: human | Application: WB - Integrating network pharmacology and transcriptomics reveals that Bushen Huoxue recipe ameliorates ferroptosis and apoptosis in granulosa cells by regulating PI3K/Akt signaling pathway in premature ovarian insufficiency mice
Journal: J Ethnopharmacol | Authors: Yanjing Huang | Species: mouse | Application: WB - Juglans regia L. attenuate Psoralea corylifolia L.-induced hepatotoxicity by regulating the Nrf2 pathway and amino acid metabolism.
Journal: J Ethnopharmacol | Authors: Yu Wu | Species: rat | Application: WB,IHC - Apple Polyphenols Improve Intestinal Antioxidant Capacity and Barrier Function by Activating the Nrf2/Keap1 Signaling Pathway in a Pig Model.
Journal: J Agric Food Chem | Authors: Tengteng Huang | Species: pig | Application: WB - Cinnamaldehyde Alleviates Bone Loss by Targeting Oxidative Stress and Mitochondrial Damage via the Nrf2/HO-1 Pathway in BMSCs and Ovariectomized Mice
Journal: J Agric Food Chem | Authors: Bing-Hao Lin | Species: mouse | Application: WB,IHC - Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism.
Journal: J Agric Food Chem | Authors: Shanshan Hu | Species: mouse | Application: WB - Hypoxia-activated dual donors of H(2)S and NO alleviate myocardial injury in coronary heart disease via synergistic mechanisms.
Journal: Eur J Med Chem | Authors: Wen Zhou | Species: rat | Application: WB - Luteolin/polyvinyl alcohol/sodium alginate hydrogel enhances fibroblast-mediated tissue repair and facilitates pressure injury healing.
Journal: Biomater Adv | Authors: Wenyi Huang - Design, synthesis and biological evaluation of 2-arylbenzo[b]furan-4-vinylcarbonyl derivatives based on Salvianolic acid C as antioxidant neuroprotective agents for the treatment of ischemic stroke
Journal: Eur J Med Chem | Authors: Wei Su | Species: rat | Application: WB - Design, synthesis and biological evaluation of 2-arylbenzo[b]furan-4-vinylcarbonyl derivatives based on Salvianolic acid C as antioxidant neuroprotective agents for the treatment of ischemic stroke
Journal: Eur J Med Chem | Authors: Wei Su | Species: rat | Application: WB - The mitochondria-targeted antioxidant MitoQ ameliorates inorganic arsenic-induced DCs/Th1/Th2/Th17/Treg differentiation partially by activating PINK1-mediated mitophagy in murine liver
Journal: Ecotoxicol Environ Saf | Authors: Hui Li | Species: mouse | Application: WB - Inorganic arsenic and its methylated metabolites induce pulmonary immunosuppression via the p62-Keap1-Nrf2 positive feedback loop-mediated M2 macrophage polarization.
Journal: Ecotoxicol Environ Saf | Authors: Xiaoxi Wei | Species: mouse | Application: WB - Integration of proteomics and metabolomics analysis investigate mechanism of As-induced immune injury in rat spleen
Journal: Ecotoxicol Environ Saf | Authors: Xiaoqian Ran | Species: rat | Application: WB - Tubuloside A attenuates sepsis-induced acute lung injury by modulating the NF-κB p50-Nrf2/GPX4 axis to suppress inflammation, oxidative stress and ferroptosis.
Journal: Biochem Pharmacol | Authors: Tianyue Guan | Species: mouse | Application: WB - PTBP1 acts as a tumor suppressor in glioma by promoting HMOX1-dependent ferroptosis
Journal: Biochem Pharmacol | Authors: Jing Sun | Species: human | Application: WB - Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth
Journal: Cell Biosci | Authors: Hongting Zhao | Species: human | Application: WB - Diverging targets mediate the pathological roleof miR-199a-5p and miR-199a-3p by promoting cardiac hypertrophy and fibrosis
Journal: Mol Ther Nucleic Acids | Authors: Ni Zeng | Species: mouse | Application: WB - Comparative effects of dietary resveratrol and pterostilbene on meat quality, muscle antioxidant capacity, and muscle fiber composition in finishing pigs.
Journal: Meat Sci | Authors: Tengteng Huang | Species: pig | Application: WB - Ginsenoside Rk1 improves endothelial function in diabetes through activating peroxisome proliferator-activated receptors
Journal: Food Funct | Authors: Lingchao Miao | Species: mouse | Application: WB - Multi-omics integration reveals that pterostilbene ameliorates cyclophosphamide-induced liver injury via the gut-liver axis by inhibiting inflammation and oxidative stress.
Journal: Food Funct | Authors: Huijie Gao - Cardamonin protects against diabetic cardiomyopathy by activating macrophage NRF2 signaling through molecular interaction with KEAP1
Journal: Food Funct | Authors: Wenshan Nan | Species: mouse | Application: WB - Dietary dihydromyricetin supplementation enhances antioxidant capacity and improves lipid metabolism in finishing pigs.
Journal: Food Funct | Authors: Zhongyang Guo | Species: pig | Application: WB - Multi-omics integration reveals that pterostilbene ameliorates cyclophosphamide-induced liver injury via the gut-liver axis by inhibiting inflammation and oxidative stress.
Journal: Food Funct | Authors: Huijie Gao - Carnosol mitigates Ang II-stimulated vascular injury and oxidative stress by directly binding to FAK and inhibiting its activation
Journal: Inflammopharmacology | Authors: Yucheng Jiang | Species: human | Application: WB - Suppression of colonic oxidative stress caused by chronic ethanol administration and attenuation of ethanol-induced colitis and gut leakiness by oral administration of sesaminol in mice
Journal: Food Funct | Authors: Hideo Ohira | Species: mouse | Application: WB - Cardamonin protects against diabetic cardiomyopathy by activating macrophage NRF2 signaling through molecular interaction with KEAP1
Journal: Food Funct | Authors: Wenshan Nan | Species: mouse | Application: WB - Minocycline alleviates microglia ferroptosis by inhibiting HO-1 during cerebral ischemia-reperfusion injury
Journal: Inflamm Res | Authors: Lin Wang | Species: rat | Application: IHC,IF - Minocycline alleviates microglia ferroptosis by inhibiting HO-1 during cerebral ischemia-reperfusion injury
Journal: Inflamm Res | Authors: Lin Wang | Species: rat | Application: IHC,IF - MLK3 promotes atherosclerosis by regulating ferroptosis in macrophages.
Journal: Inflamm Res | Authors: Hongkui Chen - Ganoderic Acid a Promotes Functional Recovery After Traumatic Brain Injury By Protecting Blood-brain Barrier Integrity and Modulating Microglial Polarization.
Journal: J Neuroimmune Pharmacol | Authors: Jianfei Wu | Species: mouse | Application: WB - HMOX1+ macrophages determine immunosuppressive microenvironment and immunotherapy efficacy in hepatocellular carcinoma.
Journal: Hepatol Commun | Authors: Yabing Du | Species: human | Application: IF - Evidence for Cytoprotective Effect of Carbon Monoxide Donor in the Development of Acute Esophagitis Leading to Acute Esophageal Epithelium Lesions.
Journal: Cells | Authors: Katarzyna Magierowska | Species: rat | Application: IHC - Isoquercitrin-loaded adipose-derived stem cell exosomes synchronize immunomodulation and neurovascular remodeling to accelerate spinal cord regeneration.
Journal: Int J Pharm | Authors: Wenjun Xia - Evidence for Cytoprotective Effect of Carbon Monoxide Donor in the Development of Acute Esophagitis Leading to Acute Esophageal Epithelium Lesions.
Journal: Cells | Authors: Katarzyna Magierowska | Species: rat | Application: IHC - Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets.
Journal: Nutrients | Authors: Youxia Wang | Species: pig | Application: WB - Hawk Tea Flavonoids as Natural Hepatoprotective Agents Alleviate Acute Liver Damage by Reshaping the Intestinal Microbiota and Modulating the Nrf2 and NF-κB Signaling Pathways
Journal: Nutrients | Authors: Ting Xu | Species: mouse | Application: WB - Protective Effects of Black Rice Anthocyanins on D-Galactose-Induced Renal Injury in Mice: The Role of Nrf2 and NF-κB Signaling and Gut Microbiota Modulation
Journal: Nutrients | Authors: Dan Sun | Species: mouse | Application: WB - Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells
Journal: Mar Drugs | Authors: Jia-Rong Hou | Species: human | Application: WB - Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway
Journal: Mar Drugs | Authors: Jiena Ye | Species: human | Application: WB - Oligo-peptide I-C-F-6 mitigates polymicrobial sepsis-induced cardiac dysfunction in mice
Journal: Eur J Pharmacol | Authors: Hongxiao Li | Application: WB - Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells
Journal: Mar Drugs | Authors: Jia-Rong Hou | Species: human | Application: WB - Heme Oxygenase-1 Regulates Zearalenone-Induced Oxidative Stress and Apoptosis in Sheep Follicular Granulosa Cells
Journal: Int J Mol Sci | Authors: Yina Li | Species: sheep | Application: WB - Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
Journal: Int Immunopharmacol | Authors: Kang Huo | Species: mouse | Application: WB - Isofraxidin attenuates dextran sulfate sodium-induced ulcerative colitis through inhibiting pyroptosis by upregulating Nrf2 and reducing reactive oxidative species
Journal: Int Immunopharmacol | Authors: Shuang He | Species: mouse | Application: WB - Deficiency of NRF2 aggravates BLM-induced systemic sclerosis-associated fibrosis and inflammation in mice.
Journal: Int Immunopharmacol | Authors: Qianyu Zhu | Species: mouse | Application: WB - Splenic Macrophage Activation and Disordered Heme-Iron Metabolism in a Mouse Model of Acute Hepatic Encephalopathy.
Journal: Int J Mol Sci | Authors: Kanako Tadokoro | Species: mouse | Application: IHC - Epoxymicheliolide prevents dextran sulfate sodium-induced colitis in mice by inhibiting TAK1-NF-κB pathway and activating Keap1-NRF2 signaling in macrophages
Journal: Int Immunopharmacol | Authors: Jinchen He | Species: mouse | Application: WB - Combination RSL3 Treatment Sensitizes Ferroptosis- and EGFR-Inhibition-Resistant HNSCCs to Cetuximab
Journal: Int J Mol Sci | Authors: Shujie Liu | Species: human | Application: WB - Phillyrin: A potential therapeutic agent for osteoarthritis via modulation of NF-κB and Nrf2 signaling pathways
Journal: Int Immunopharmacol | Authors: Jiawei Ma | Species: mouse | Application: WB - Heme Oxygenase-1 Regulates Zearalenone-Induced Oxidative Stress and Apoptosis in Sheep Follicular Granulosa Cells
Journal: Int J Mol Sci | Authors: Yina Li | Species: sheep | Application: WB - Activation of the Nrf2 Signaling Pathway by Tetrahydroberberine Suppresses Ferroptosis and Enhances Functional Recovery Following Spinal Cord Injury
Journal: Mol Neurobiol | Authors: Xiang Li | Species: mouse | Application: WB,IF - PrPSc Inhibition and Cellular Protection of DBL on a Prion-Infected Cultured Cell via Multiple Pathways.
Journal: Mol Neurobiol | Authors: Wei Yang | Species: mouse | Application: WB - Oral Administrations of Short-Chain Fatty Acids or Probiotics Extend the Survival Times and Mitigate the Neuropathological Damages in the Scrapie-Infected Hamsters.
Journal: Mol Neurobiol | Authors: Yuan Wang | Species: hamster | Application: IHC - Activation of the Nrf2 Signaling Pathway by Tetrahydroberberine Suppresses Ferroptosis and Enhances Functional Recovery Following Spinal Cord Injury
Journal: Mol Neurobiol | Authors: Xiang Li | Species: mouse | Application: WB,IF - Bioactive ROS-Responsive Nanotherapeutics Attenuate Intermittent Hypoxia-Induced Cognitive Impairment via NRF2/KEAP1/HO-1 Signaling
Journal: Neurochem Int | Authors: Yinpei Huang | Species: rat,mouse | Application: WB - GSK3β Substrate-competitive Inhibitors Regulate the gut Homeostasis and Barrier Function to Inhibit Neuroinflammation in Scopolamine-induced Alzheimer's Disease Model Mice
Journal: Inflammation | Authors: Lingyu Zhang | Species: mouse | Application: WB - Chinese Herbal Preparation SaiLuoTong Alleviates Brain Ischemia via Nrf2 Antioxidation Pathway-Dependent Cerebral Microvascular Protection
Journal: Front Pharmacol | Authors: Xiao-Di Fan | Species: rat,human | Application: WB,IHC - Iridoids derived from Valeriana jatamansi Jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signaling pathway
Journal: Front Pharmacol | Authors: Yongzhi He | Species: rat | Application: WB - Bilirubin Protects Transplanted Islets by Targeting Ferroptosis.
Journal: Front Pharmacol | Authors: Qing Yao | Species: mouse | Application: WB - Fangchinoline attenuates hepatic fibrosis by regulating taurine metabolism and oxidative stress.
Journal: Front Pharmacol | Authors: Hui Yin | Species: mouse | Application: WB - GSK3β Substrate-competitive Inhibitors Regulate the gut Homeostasis and Barrier Function to Inhibit Neuroinflammation in Scopolamine-induced Alzheimer's Disease Model Mice
Journal: Inflammation | Authors: Lingyu Zhang | Species: mouse | Application: WB - Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.
Journal: Front Cell Dev Biol | Authors: Xun Xi | Species: human | Application: CoIP - Caffeic Acid Improves Intestinal Barrier Function Integrity through Activation of Nrf2 Signaling Pathway in Weaned Piglets and H2O2 Induced IPEC-J2 Cells
Journal: J Nutr Biochem | Authors: Xueya Zhu | Species: pig | Application: WB - Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in vivo.
Journal: J Nutr Biochem | Authors: Xiaoling Chen | Species: mouse | Application: WB - Astaxanthin alleviates DSS-induced ulcerative colitis in mice associated with Nrf2-mediated ferroptosis independently of gut microbiota modulation.
Journal: J Nutr Biochem | Authors: Meng-Xuan Wei | Species: mouse | Application: IF - Caffeic Acid Improves Intestinal Barrier Function Integrity through Activation of Nrf2 Signaling Pathway in Weaned Piglets and H2O2 Induced IPEC-J2 Cells
Journal: J Nutr Biochem | Authors: Xueya Zhu | Species: pig | Application: WB - Daidzein supplementation improved fecundity in sows via modulation of ovarian oxidative stress and inflammation
Journal: J Nutr Biochem | Authors: Kunhong Xie | Species: pig | Application: WB - Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2/PPARγ-GPX4-ferroptosis pathway in mice
Journal: Toxicology | Authors: Shijie Fan | Species: mouse | Application: WB - Monkfish (Lophius litulon) Peptides Ameliorate High-Fat-Diet-Induced Nephrotoxicity by Reducing Oxidative Stress and Inflammation via Regulation of Intestinal Flora
Journal: Molecules | Authors: Xiangyu Ren | Species: mouse | Application: WB - Rosmarinic Acid as a Candidate in a Phenotypic Profiling Cardio-/Cytotoxicity Cell Model Induced by Doxorubicin.
Journal: Molecules | Authors: Qiao Zhang | Species: rat | Application: WB - Antioxidant Activity of Acanthopanax senticosus Flavonoids in H2O2-Induced RAW 264.7 Cells and DSS-Induced Colitis in Mice.
Journal: Molecules | Authors: Jianqing Su | Species: mouse | Application: WB - Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Journal: Molecules | Authors: Juan Chen | Species: rat | Application: WB - Gracillin induces mitochondria-mediated apoptosis on pancreatic ductal adenocarcinoma through disruption of redox homeostasis via inhibiting NRF2/HO-1 antioxidant axis
Journal: Bioorg Chem | Authors: Woonghee Lee | Species: human | Application: WB,IHC - Monkfish (Lophius litulon) Peptides Ameliorate High-Fat-Diet-Induced Nephrotoxicity by Reducing Oxidative Stress and Inflammation via Regulation of Intestinal Flora
Journal: Molecules | Authors: Xiangyu Ren | Species: mouse | Application: WB - MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis
Journal: Oxid Med Cell Longev | Authors: Bowei Ni | Species: mouse | Application: WB - MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis
Journal: Oxid Med Cell Longev | Authors: Bowei Ni | Species: mouse | Application: WB - Involvement of NADPH oxidases in the Na/K‑ATPase/Src/ROS oxidant amplification loop in renal fibrosis
Journal: Mol Med Rep | Authors: Huimin Zhang | Species: mouse | Application: WB - Cancer cell membrane-camouflaged curcumin nanoparticles trigger ferroptosis for accurate gastric cancer therapy
Journal: Eur J Pharm Biopharm | Authors: Yuanyuan Fan | Species: human | Application: IF - Fucoxanthin Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Mice via Nrf2/HO-1/GPX4-Mediated Ferroptosis Pathway.
Journal: Food Sci Nutr | Authors: Zhongliang Liu | Species: mouse | Application: WB - Neuroprotective effect of Ginsenoside Re against neurotoxin‑induced Parkinson's disease models via induction of Nrf2.
Journal: Mol Med Rep | Authors: Juhui Qiao | Species: human | Application: WB - Polyphyllin I inhibits glioblastoma progression by initiating ferroptosis via the Sirt1/Nrf2/HO-1/GPX4 signaling cascade.
Journal: Biochim Biophys Acta Mol Basis Dis | Authors: Anhui Fu | Species: human | Application: WB - Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota
Journal: Sci Rep | Authors: Yingchun Zhao | Species: mouse | Application: WB - Punicalagin relieves hepatic injury by antioxidation and enhancement of autophagy in diet-induced nonalcoholic steatohepatitis
Journal: Sci Rep | Authors: Li Ma | Species: mouse | Application: WB - The protecting role of Ganoderma lucidum polysaccharides on the retinal neurovascular units in rats with retinal ischemia-reperfusion injury.
Journal: Sci Rep | Authors: Diege Long | Species: rat | Application: WB - Protective effects and mechanisms of high-dose vitamin C on sepsis-associated cognitive impairment in rats
Journal: Sci Rep | Authors: Ning Zhang | Species: rat | Application: WB - Loss of Brg1 prevents the progression of pulmonary hypertension by inhibiting Nrf2 expression.
Journal: Sci Rep | Authors: Wen-Di Jiang - Tertiary butylhydroquinone regulates oxidative stress in spleen injury induced by gas explosion via the Nrf2/HO-1 signaling pathway
Journal: Sci Rep | Authors: Jing Ma | Species: rat | Application: WB - Tertiary butylhydroquinone regulates oxidative stress in spleen injury induced by gas explosion via the Nrf2/HO-1 signaling pathway
Journal: Sci Rep | Authors: Jing Ma | Species: rat | Application: WB - 4-Octyl itaconate ameliorates cigarette smoke-induced chronic obstructive pulmonary disease by suppressing necroptosis in alveolar macrophages via Nrf2 activation.
Journal: Sci Rep | Authors: Zhe Wang - Sestrin2 ameliorates LPS-induced cardiomyocyte injury by inhibiting ferroptosis via the Nrf2/HO-1 pathway.
Journal: Eur J Med Res | Authors: Yiheng Yang | Species: rat | Application: WB - Quercetin alleviates radiation-induced erectile dysfunction by modulating oxidative stress and apoptosis through the Nrf2/HO-1 pathway.
Journal: Eur J Med Res | Authors: Hongyu Liu | Species: rat | Application: IF - Salvianolic acid B attenuates post-cardiac arrest cerebral ischemia-reperfusion injury via activation of the Nrf2 signaling pathway.
Journal: Eur J Med Res | Authors: Chuanbao Lv | Species: rat | Application: WB - Catharanthine tartrate ameliorates osteoclastogenesis by destabilizing HIF-1α
Journal: Cell Signal | Authors: Luqiong Cai | Species: mouse | Application: WB - Costunolide alleviates hyperglycaemia-induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress
Journal: J Cell Mol Med | Authors: Bo Jin | Species: rat,mouse | Application: WB - Catharanthine tartrate ameliorates osteoclastogenesis by destabilizing HIF-1α
Journal: Cell Signal | Authors: Luqiong Cai | Species: mouse | Application: WB - Ethyl Acetate Extract of Elsholtzia bodinieri Vaniot Attenuates Oxidative Stress in ALI Mice
Journal: J Inflamm Res | Authors: Haiaolong Yin | Application: WB - Glycyrrhiza uralensis Fisch. and its active components mitigate Semen Strychni-induced neurotoxicity through regulating high mobility group box 1 (HMGB1) translocation.
Journal: Biomed Pharmacother | Authors: Xiaoyu Duan | Species: rat | Application: WB - Dietary Ferulic Acid Increases Endurance Capacity by Promoting Skeletal Muscle Oxidative Phenotype, Mitochondrial Function, and Antioxidant Capacity
Journal: Mol Nutr Food Res | Authors: Tengteng Huang | Species: mouse - HMOX1 drives dihydroartemisinin-sensitized ferroptosis antagonized by mitochondrial fusion.
Journal: iScience | Authors: Zi-Jie Deng | Species: rat, mouse | Application: WB - Resveratrol alleviates depression-like behaviors by inhibiting ferroptosis via AKT/NRF2 pathway
Journal: Brain Res Bull | Authors: Chen Li | Species: rat | Application: WB - HMOX1 drives dihydroartemisinin-sensitized ferroptosis antagonized by mitochondrial fusion.
Journal: iScience | Authors: Zi-Jie Deng | Species: rat, mouse | Application: WB - Aberrant Reduction of Short-Chain Fatty Acid (SCFA) Receptor GPR41 and Transporter MCT4 in Prion-Infected Rodent and Cell Models
Journal: ACS Chem Neurosci | Authors: Yuan Wang | Species: mouse | Application: WB - The regenerating skeletal muscle niche drives satellite cell return to quiescence.
Journal: iScience | Authors: Alicia A Cutler | Species: mouse | Application: IF - CDK1 regulates NRF2 stability through phosphorylation of USP29 and inhibits neuronal ferroptosis after traumatic brain injury.
Journal: Brain Res Bull | Authors: Mengze Wang - Shikonin Attenuates Cochlear Spiral Ganglion Neuron Degeneration by Activating Nrf2-ARE Signaling Pathway.
Journal: Front Mol Neurosci | Authors: Hongjie Du | Species: mouse | Application: WB - Vitamin D receptor alleviates lipid peroxidation in diabetic nephropathy by regulating ACLY/Nrf2/Keap1 pathway
Journal: FASEB J | Authors: Yueyi Zhou | Species: mouse | Application: WB - Artesunate does not prevent cardiac hypertrophy but inhibits heart failure progression in mice.
Journal: J Pharmacol Exp Ther | Authors: Anna Zhang - T-2 Toxin Induces Apoptotic Cell Death and Protective Autophagy in Mouse Microglia BV2 Cells.
Journal: J Fungi (Basel) | Authors: Tun Sun | Species: mouse | Application: WB - Nrf2 maintains reactive oxygen species at an optimal level during endoplasmic reticulum stress in HT22 cells.
Journal: Eur J Cell Biol | Authors: Yoko Hirata | Species: mouse | Application: WB - Selenized Probiotic L. brevis 23017 Alleviates Colitis by Modulating the Nrf2-GPX4 Axis to Inhibit Ferroptosis.
Journal: Biol Trace Elem Res | Authors: Yuxin Zhuang | Species: mouse | Application: WB - Apigenin alleviates DFZ-induced cardiac, renal, and intestinal injury in carp by modulating oxidative stress and inflammatory responses.
Journal: Fish Shellfish Immunol | Authors: Tianyue Guan | Application: WB - Apigenin alleviates DFZ-induced cardiac, renal, and intestinal injury in carp by modulating oxidative stress and inflammatory responses.
Journal: Fish Shellfish Immunol | Authors: Tianyue Guan | Application: WB - Potential therapeutic effect of dimethyl fumarate on Treg/Th17 cell imbalance in biliary atresia
Journal: Clin Immunol | Authors: Mengting Liu | Species: mouse | Application: WB - Dietary supplementation with pterostilbene improves the water-holding capacity of pork in finishing pigs.
Journal: J Sci Food Agric | Authors: Tengteng Huang | Species: pig | Application: WB - Dexmedetomidine attenuates ferroptosis by Keap1-Nrf2/HO-1 pathway in LPS-induced acute kidney injury
Journal: Naunyn Schmiedebergs Arch Pharmacol | Authors: Rui-Rui Luo | Species: mouse | Application: WB - Integrating UPLC-HR-MS, network pharmacology and experimental validation to reveal the potential mechanism of Fuzheng Bixie granules in treating acute lung injury.
Journal: Naunyn Schmiedebergs Arch Pharmacol | Authors: Luyin Yang | Species: mouse | Application: WB - Gut-liver axis mediates the ameliorative effects of North Hawthorn polysaccharide on liver inflammation and oxidative stress in hyperlipidemic mice via Nrf2 signaling pathway.
Journal: Food Sci Biotechnol | Authors: Shi Lingling | Species: mouse | Application: WB - Increased ROS levels activate AMPK-ULK1-mediated mitophagy to promote pseudorabies virus replication.
Journal: Vet Res | Authors: Yuan Zhao | Species: pig | Application: WB - BACH1 regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells
Journal: BMC Oral Health | Authors: C. Liu | Species: human | Application: IF - Phillyrin prevents calcium oxalate kidney stones through the PPARγ signaling pathway
Journal: Ren Fail | Authors: Xiaohan Chu - Induction of Nrf2 pathway by Dendrobium nobile Lindl. alkaloids protects against carbon tetrachloride induced acute liver injury.
Journal: Biomed Pharmacother | Authors: Shiyue Li | Species: mouse | Application: WB - An H₂S-releasing oridonin derivative protects HaCaT cells against metabolic stress via PI3K/AKT/Nrf2 signaling.
Journal: Mol Immunol | Authors: Lang Lin | Species: human | Application: WB - G0S2 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell injury by regulating mitochondrial apoptosis
Journal: Ann Transl Med | Authors: Zenghui Liang | Species: human | Application: WB - IL-35 alleviates ferroptosis in macrophage by activating the NRF2/GPX4 pathway to improve sepsis-induced ARDS.
Journal: Cytokine | Authors: Panting Liu | Species: mouse | Application: WB - Overexpression of Decorin Optimizes the Treatment Efficacy of Umbilical Cord Mesenchymal Stem Cells in Bleomycin-Induced Pulmonary Fibrosis in Rats
Journal: Stem Cells Int | Authors: Yaofeng Zhi | Species: rat | Application: IHC - Protective Effects of Hyperoside on Type 2 Diabetes Through the Regulation of Pancreatic β-cell Function.
Journal: Immun Inflamm Dis | Authors: Yuanyuan Jia - Exosomes derived from HISLA overexpressed-adipose stem cells accelerate wound healing in diabetic foot ulcers by regulating HIF-1α signal transduction.
Journal: Arch Biochem Biophys | Authors: Wei Zhao - CircYTHDF1/miR-19b-3p/YTHDF1 axis contributes to pregnancy-induced hypertension development by enhancing vascular endothelial cell injury
Journal: Hypertens Pregnancy | Authors: Fangyun Wang | Species: human | Application: WB - Morroniside maintains mitochondrial homeostasis in microglia and mitigates neuroinflammation in experimental autoimmune encephalomyelitis.
Journal: J Neuropathol Exp Neurol | Authors: Shaopeng Zhai | Species: mouse | Application: WB - Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of velvet antler in the treatment of chronic atrophic gastritis.
Journal: J Food Drug Anal | Authors: Quan Liao | Species: human | Application: WB - Formononetin attenuates LPS-induced neuroinflammation and depressive-like behaviors by regulating the Keap1/Nrf2/HO-1 pathway in the hippocampus.
Journal: Neuroscience | Authors: Siqi Quan - The effect of Hydrogen-rich water on retinal degeneration in the outer nuclear layer of simulated weightlessness rats
Journal: Life Sci Space Res (Amst) | Authors: Yuxue Mu | Species: rat | Application: WB - Morroniside maintains mitochondrial homeostasis in microglia and mitigates neuroinflammation in experimental autoimmune encephalomyelitis.
Journal: J Neuropathol Exp Neurol | Authors: Shaopeng Zhai | Species: mouse | Application: WB - Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 cells by regulating apoptotic and Nrf2/p62 pathways.
Journal: Food Chem Toxicol | Authors: Lei Zhao | Species: human | Application: WB - Soy Isoflavone Supplementation in Sow Diet Enhances Antioxidant Status and Promotes Intestinal Health of Newborn Piglets.
Journal: Animals (Basel) | Authors: Le Liu | Species: pig | Application: WB,IF - Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway.
Journal: Animals (Basel) | Authors: Shichao Guo | Species: mouse | Application: IF - Soy Isoflavone Supplementation in Sow Diet Enhances Antioxidant Status and Promotes Intestinal Health of Newborn Piglets.
Journal: Animals (Basel) | Authors: Le Liu | Species: pig | Application: WB,IF - Decreased PLK2 promotes atrial fibrillation in diabetic mice through Nrf2/HO-1 pathway
Journal: Acta Diabetol | Authors: Huan-Huan Liu | Species: mouse | Application: WB - Huangqin Decoction Delays Progress of Colitis-Associated Carcinogenesis by Regulating Nrf2/HO-1 Antioxidant Signal Pathway in Mice
Journal: Chin J Integr Med | Authors: Li-Mei Gu | Species: mouse | Application: WB,IHC - Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner.
Journal: Tissue Cell | Authors: Xiangyou Yu | Species: mouse | Application: WB - Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain.
Journal: Toxicol Mech Methods | Authors: Shixin Tang | Species: mouse | Application: WB - Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by Aβ25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway.
Journal: Biomed Res Int | Authors: Xinjun Yu | Species: rat | Application: WB - Metformin attenuates PM2.5-induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells
Journal: Toxicol Mech Methods | Authors: Jing Cui | Species: mouse | Application: WB - Zerumbone attenuates the excessive proliferation of keratinocytes in psoriasis mice through regulating NLRP3/NF-κB pathway
Journal: Toxicol Res (Camb) | Authors: Jin Lin | Species: mouse | Application: WB - Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain.
Journal: Toxicol Mech Methods | Authors: Shixin Tang | Species: mouse | Application: WB - Menstrual Blood-Derived Endometrial Stem Cells Ameliorate Ovarian Senescence by Relieving Oxidative Stress-Induced Inflammation
Journal: Reprod Sci | Authors: Haofeng Song | Species: mouse,human | Application: WB - Knocking down FAM110A suppresses colon adenocarcinoma progression by inhibiting the Nrf2/HO-1 axis to induce ferroptosis.
Journal: World J Surg Oncol | Authors: Qilong Li | Species: human | Application: WB - Knocking down FAM110A suppresses colon adenocarcinoma progression by inhibiting the Nrf2/HO-1 axis to induce ferroptosis.
Journal: World J Surg Oncol | Authors: Qilong Li | Species: human | Application: WB - Dapagliflozin inhibits ferroptosis to improve chronic heart failure by regulating Nrf2/HO-1/GPX4 signaling pathway
Journal: PLoS One | Authors: Jing Zhang | Species: rabbit | Application: WB - Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.
Journal: FEBS Open Bio | Authors: Na Wei | Species: mouse | Application: WB - Bioinformatics analysis of ferroptosis in frozen shoulder
Journal: BMC Med Genomics | Authors: Hongcui Zhang | Species: rat | Application: WB - High Salt Exacerbates Myocardial Dysfunction In Vitro and In Vivo by Promoting SIRT1/Nrf2-Mediated Ferroptosis
Journal: Clin Exp Pharmacol Physiol | Authors: Wu Guanji | Species: rat | Application: WB - Activation of the Nuclear Erythroid 2-Related Factor 2 Antioxidant Responsive Element (Nrf2-ARE) Signaling Pathway Alleviates Acute Graft-Versus-Host Disease by Reducing Oxidative Stress and Inhibiting Infiltration of Inflammatory Cells in an Allogeneic Stem Cell Transplantation Mouse Model.
Journal: Med Sci Monit | Authors: Ting Yi | Species: mouse | Application: WB - Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway.
Journal: Biochem Biophys Res Commun | Authors: Zhuolin Zhou | Species: mouse | Application: WB - Activation of the Nuclear Erythroid 2-Related Factor 2 Antioxidant Responsive Element (Nrf2-ARE) Signaling Pathway Alleviates Acute Graft-Versus-Host Disease by Reducing Oxidative Stress and Inhibiting Infiltration of Inflammatory Cells in an Allogeneic Stem Cell Transplantation Mouse Model.
Journal: Med Sci Monit | Authors: Ting Yi | Species: mouse | Application: WB - Oxycodone attenuates endotoxin-induced acute lung injury by regulating mitophagy via the HO-1 pathway.
Journal: Clinics (Sao Paulo) | Authors: Cuicui Liu | Species: mouse | Application: IF - Orientin inhibits inflammation in chondrocytes and attenuates osteoarthritis through Nrf2/NF-κB and SIRT6/NF-κB pathway
Journal: J Orthop Res | Authors: Weiyi Xia | Species: mouse | Application: WB - Multi-omics Analysis Uncovers TFRC/HMOX1-dependent Ferroptosis Mediating Celastrol's Anti-invasive/Metastatic Effects on Esophageal Squamous Cell Carcinoma.
Journal: Recent Pat Anticancer Drug Discov | Authors: Yulong Zha - The neuroprotective effect of LCZ696 on methamphetamine-induced cognitive impairment in mice
Journal: Neurosci Lett | Authors: Liyin Qian | Species: human | Application: WB - Role of CYP4F2 as a novel biomarker regulating malignant phenotypes of liver cancer cells via the Nrf2 signaling axis.
Journal: Oncol Lett | Authors: Shunyuan Wan | Species: human | Application: WB - Dietary ferulic acid supplementation improves intestinal antioxidant capacity and intestinal barrier function in weaned piglets.
Journal: Anim Biotechnol | Authors: Xiaoling Chen | Species: pig | Application: WB - Dietary L-theanine supplementation improves lipid metabolism and antioxidant capacity in weaning piglets.
Journal: Anim Biotechnol | Authors: Xiaoling Chen | Species: pig | Application: WB - Dietary grape seed proanthocyanidin extract supplementation improves antioxidant capacity and lipid metabolism in finishing pigs
Journal: Anim Biotechnol | Authors: Yadi Feng | Species: pig | Application: WB - Senolytics alleviate cyclophosphamide-induced premature ovarian insufficiency by eliminating senescent cells.
Journal: Eur J Histochem | Authors: Huina Su | Species: mouse | Application: IHC - CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
Journal: Open Med (Wars) | Authors: Xi Yan | Species: human | Application: IHC - CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
Journal: Open Med (Wars) | Authors: Xi Yan | Species: human | Application: IHC - Kuwanon C alleviates pulmonary fibrosis via activation of the Nrf2 signaling pathway.
Journal: J Asian Nat Prod Res | Authors: Qian Wang - Apple polyphenols improve intestinal barrier function by enhancing antioxidant capacity and suppressing inflammation in weaning piglets
Journal: Anim Sci J | Authors: Zhongyang Guo | Species: pig | Application: WB - HO-1: a new marker for predicting postoperative recurrence of CRSwNP
Journal: Acta Otolaryngol | Authors: Min-Jie Gong | Species: human | Application: IHC - Curcumin Analogues Trigger HMOX1-Mediated Ferroptosis to Halt Endometrial Cancer Growth.
Journal: bioRxiv | Authors: Xiangxiang Wu | Species: human | Application: WB - NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion
Journal: bioRxiv | Authors: Michael S Dahabieh | Species: mouse | Application: WB - Naringenin restores neuronal membrane electro-biophysical homeostasis: insights from EIS circuit modeling and molecular dynamics.
Journal: Front Med (Lausanne) | Authors: Yiyao Zhang - A universal consuming endogenous H(2)S strategy using bismuth-metal-organic nanocapsule networks for overcoming osteosarcoma cisplatin resistance.
Journal: Bioact Mater | Authors: Yixuan Lin - African swine fever virus impairs porcine alveolar macrophages bactericidal function by disrupting lysosomal acidification and cathepsin activity.
Journal: PLoS Pathog | Authors: Zhen Xu - Luteolin ameliorates sympathetic stress-induced myocardial injury by inhibiting the VEGFA/VEGFR2 and PI3K/Akt/NF-kappaB signaling pathways.
Journal: Naunyn Schmiedebergs Arch Pharmacol | Authors: Sheng Li
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