CD41 Recombinant monoclonal antibody 87447-4-RR proteintech
$149.00
In stock
SKU
87447-4-RR
| Catalog Number | 87447-4-RR |
| Synonyms | CD41a, CD41B, GP2B, GPalpha IIb, GPIIb |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | human peripheral blood platelets |
| Recommended Dilutions — Western Blot (WB) | WB : 1:5000-1:50000 |
| Positive WB detected in | human peripheral blood platelets |
| Western Blot (WB) | WB : 1:5000-1:50000 |
| Tested Reactivity | human |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | CatNo: Eg10496 Product name: Recombinant human ITA2B protein Source: mammalian cells -derived, pHZ-KIsec-C-6*HIS Tag: C-Twin-Strep-Tag Domain: 10011419 of Sequence: \ Predict reactive species |
| Full Name | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
| Observed Molecular Weight | 110-125 kDa |
| Gene Symbol | CD41 |
| Gene ID (NCBI) | 3674 |
| RRID | AB_3745552 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | P08514 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for CD41 antibody 87447-4-RR | Download protocol |
| Citations | - |
| Dilutions | WB : 1:5000-1:50000 |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 252680C11 |
| Conjugation | Unconjugated |
The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses, including migration, proliferation, differentiation, and apoptosis (PMID: 19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light beta (25 kDa) and heavy alpha (125 kDa) chains, which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. CD41/CD61 is crucial for platelet aggregation through binding of soluble fibrinogen. Jurkat and U937 cell lines are negative controls for CD41 (PMID: 2351656). Protocols Product Specific Protocols WB protocol for CD41 antibody 87447-4-RR Download protocol Standard Protocols Click here to view our Standard Protocols
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