CXorf56 Polyclonal antibody 24021-1-AP proteintech
$149.00
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SKU
24021-1-AP
| Catalog Number | 24021-1-AP |
| Synonyms | STEEP, STEEP1, STING ER exit protein, UPF0428 protein CXorf56 |
| Host | Rabbit |
| Reactivity | human, mouse and More (1) |
| Reactivity | human, mouse, monkey |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IF/ICC, IP, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | HeLa cells, HEK-293 cells, mouse kidney tissue |
| Tested Applications — Positive IP detected in | mouse kidney tissue |
| Tested Applications — Positive IF/ICC detected in | HeLa cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:4000 |
| Recommended Dilutions — Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Recommended Dilutions — Immunofluorescence (IF)/ICC | IF/ICC : 1:20-1:200 |
| Positive WB detected in | HeLa cells, HEK-293 cells, mouse kidney tissue |
| Positive IP detected in | mouse kidney tissue |
| Positive IF/ICC detected in | HeLa cells |
| Western Blot (WB) | WB : 1:500-1:4000 |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:20-1:200 |
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, monkey |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag19856 Product name: Recombinant human CXorf56 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-222 aa of BC023506 Sequence: MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRSRVIDAAKHAHKFCNTEDEETMYLRRPEGIERQYRKKCAKCGLPLFYQSQPKNAPVTFIVDGAVVKFGQGFGKTNIYTQKQEPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREVADSYAQNAKVIEKQLERKGMSKRRLQELAELEAKKAKMKGTLIDNQFK Predict reactive species |
| Full Name | chromosome X open reading frame 56 |
| Calculated Molecular Weight | 222 aa, 26 kDa |
| Observed Molecular Weight | 26-30 kDa |
| GenBank Accession Number | BC023506 |
| Gene Symbol | CXorf56 |
| Gene ID (NCBI) | 63932 |
| RRID | AB_2879404 |
| Conjugate | Unconjugated |
| Purification Method | Antigen Affinity purified |
| UNIPROT ID | Q9H5V9 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IF protocol for CXorf56 antibody 24021-1-AP | Download protocol |
| IP protocol for CXorf56 antibody 24021-1-AP | Download protocol |
| WB protocol for CXorf56 antibody 24021-1-AP | Download protocol |
| human | WB Nat Commun Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds Authors - Bao-Cun Zhang View Article |
| monkey | WB J Virol The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1 Authors - Feifei Diao View Article |
| Citations | 4 |
| Dilutions | WB : 1:500-1:4000 IP : 0.5-4.0 ug for IP and 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate for WB IF/ICC : 1:20-1:200 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
CxORF56 (also known as STEEP) is an evolutionarily highly conserved protein whose function is unknown. Recently CxORF56 has been identified as a protein that interacts with STING, and it is essential for STING ER exit. CxORF56-dependent STING ER exit is essential for STING signaling in antiviral defense and in inflammatory diseases. Protocols Product Specific Protocols IF protocol for CXorf56 antibody 24021-1-AP Download protocol IP protocol for CXorf56 antibody 24021-1-AP Download protocol WB protocol for CXorf56 antibody 24021-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology.
Journal: EBioMedicine | Authors: Thaneas Prabakaran | Species: human | Application: WB - The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1
Journal: J Virol | Authors: Feifei Diao | Species: monkey | Application: WB - Inhibition of CXorf56 promotes PARP inhibitor-induced cytotoxicity in triple-negative breast cancer
Journal: NPJ Breast Cancer | Authors: Ying Zhu | Species: human | Application: WB,IP - Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds
Journal: Nat Commun | Authors: Bao-Cun Zhang | Species: human | Application: WB
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