Collagen Type XI Polyclonal antibody 21841-1-AP proteintech
$149.00
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SKU
21841-1-AP
| Catalog Number | 21841-1-AP |
| Synonyms | COL11, COL11A1, CO11A1, COLL6, Collagen alpha 1(XI) chain |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, IF-P, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | U2OS cells |
| Tested Applications — Positive IHC detected in | human placenta tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Tested Applications — Positive IF-P detected in | human placenta tissue |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:2000 |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Recommended Dilutions — Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| Positive WB detected in | U2OS cells |
| Positive IHC detected in | human placenta tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human placenta tissue |
| Western Blot (WB) | WB : 1:500-1:2000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| Tested Reactivity | human |
| Cited Reactivity | human |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag16509 Product name: Recombinant human COL11A1 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1429-1690 aa of BC117697 Sequence: PLPILSSKKTRRHTEGMQADADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKLLSYLDVEGNSINMVQMTFLKLLTASARQNFTYHCHQSAAWYDVSSGSYDKALRFLGSNDEEMSYDNNPFIKTLYDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG Predict reactive species |
| Full Name | collagen, type XI, alpha 1 |
| Calculated Molecular Weight | 1818 aa, 182 kDa |
| Observed Molecular Weight | 250 kDa, 181 kDa |
| GenBank Accession Number | BC117697 |
| Gene Symbol | COL11A1 |
| Gene ID (NCBI) | 1301 |
| RRID | AB_2918074 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P12107 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IF protocol for Collagen Type XI antibody 21841-1-AP | Download protocol |
| IHC protocol for Collagen Type XI antibody 21841-1-AP | Download protocol |
| WB protocol for Collagen Type XI antibody 21841-1-AP | Download protocol |
| human | IHC Front Immunol COL11A1 as an novel biomarker for breast cancer with machine learning and immunohistochemistry validation Authors - Wenjie Shi View Article |
| Citations | 9 |
| Dilutions | WB : 1:500-1:2000 IHC : 1:50-1:500 IF-P : 1:50-1:500 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
COL11A1 is an important component of collagen XI and is considered to play an important role in a variety of connective tissue diseases. Type XI collagen is widely distributed in tissues including cartilage, bone, and muscle, and its hereditary absence in Marshall's syndrome, Stickler's syndrome, fibrochondrogenesis, and nonsyndromic hearing loss deafness, autosomal dominant 37 leads to facial and eye abnormalities, hearing loss, and joint problems. The COL11A1 expression was significantly correlated with the degree of immune infiltration and the expression of a variety of immune cell markers in tumor tissue. (PMID: 36160004 33610546) Protocols Product Specific Protocols IF protocol for Collagen Type XI antibody 21841-1-AP Download protocol IHC protocol for Collagen Type XI antibody 21841-1-AP Download protocol WB protocol for Collagen Type XI antibody 21841-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- In vivo inhibition of TDO2 in fibroids results in widespread alteration in the tumor transcriptome.
Journal: Clin Sci (Lond) | Authors: Tsai-Der Chuang | Species: human | Application: WB - Multiregion single cell analysis reveals a novel subtype of cancer-associated fibroblasts located in the hypoxic tumor microenvironment in colorectal cancer
Journal: Transl Oncol | Authors: Nanxin Zheng | Species: human | Application: IF - Increased Wnt5a/ROR2 signaling is associated with chondrogenesis in meniscal degeneration
Journal: J Orthop Res | Authors: Yusuke Inoue | Species: human | Application: IHC - Analysis of cancer-associated fibroblasts related genes identifies COL11A1 associated with lung adenocarcinoma prognosis
Journal: BMC Med Genomics | Authors: Haosheng Zheng | Species: human | Application: IHC,IF - Single-Cell Transcription Reveals the Fibroblast Heterogeneity and Neural Cells' Significance in Desmoid Fibromatosis
Journal: Cancer Sci | Authors: Junfeng Wang - COL11A1 as an novel biomarker for breast cancer with machine learning and immunohistochemistry validation
Journal: Front Immunol | Authors: Wenjie Shi | Species: human | Application: IHC
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