DNALI1 Polyclonal antibody 17601-1-AP proteintech
$149.00
In stock
SKU
17601-1-AP
| Catalog Number | 17601-1-AP |
| Synonyms | hp28, P28 |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IF, IP, CoIP, ELISA |
| Applications | WB, IP, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | mouse testis tissue, rat testis tissue |
| Tested Applications — Positive IP detected in | mouse testis tissue |
| Recommended Dilutions — Western Blot (WB) | WB : 1:2000-1:10000 |
| Recommended Dilutions — Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Positive WB detected in | mouse testis tissue, rat testis tissue |
| Positive IP detected in | mouse testis tissue |
| Western Blot (WB) | WB : 1:2000-1:10000 |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse, rat |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag11652 Product name: Recombinant human DNALI1 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-258 aa of BC046117 Sequence: MIPPADSLLKYDTPVLVSRNTEKRSPKARLLKVSPQQPGPSGSAPQPPKTKLPSTPCVPDPTKQAEEILNAILPPREWVEDTQLWIQQVSSTPSTRMDVVHLQEQLDLKLQQRQARETGICPVRRELYSQCFDELIREVTINCAERGLLLLRVRDEIRMTIAAYQTLYESSVAFGMRKALQAEQGKSDMERKIAELETEKRDLERQVNEQKAKCEATEKRESERRQVEEKKHNEEIQFLKRTNQQLKAQLEGIIAPKK Predict reactive species |
| Full Name | dynein, axonemal, light intermediate chain 1 |
| Calculated Molecular Weight | 258 aa, 30 kDa |
| Observed Molecular Weight | 30-33 kDa |
| GenBank Accession Number | BC046117 |
| Gene Symbol | DNALI1 |
| Gene ID (NCBI) | 7802 |
| RRID | AB_2095372 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O14645 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IP protocol for DNALI1 antibody 17601-1-AP | Download protocol |
| WB protocol for DNALI1 antibody 17601-1-AP | Download protocol |
| mouse | WB,IF Basic Clin Androl Dnali1 is required for sperm motility and male fertility in mice Authors - Yiling Zhou View Article |
| human | IF Clin Genet DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella. Authors - Yang Li View Article |
| rat | WB,IF Front Cell Dev Biol PIH1D3-knockout rats exhibit full ciliopathy features and dysfunctional pre-assembly and loading of dynein arms in motile cilia Authors - Tingting Zhang View Article |
| Citations | 18 |
| Dilutions | WB : 1:2000-1:10000 IP : 0.5-4.0 ug for IP and 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate for WB |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
DNALI1 belongs to the inner dynein arm light chain family and encodes a subunit of the light intermediate chain of inner dynein arms of the axoneme of sperm flagella (PMID: 36792588). DNALI1 promotes neurodegeneration after traumatic brain injury via inhibition of autophagosome-lysosome fusion (PMID: 38348540). Mutation in DNALI1 Causes Male Infertility with Severe Oligoasthenoteratozoospermia in Humans (PMID: 38212584). Protocols Product Specific Protocols IP protocol for DNALI1 antibody 17601-1-AP Download protocol WB protocol for DNALI1 antibody 17601-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- DNALI1 Promotes Neurodegeneration after Traumatic Brain Injury via Inhibition of Autophagosome-Lysosome Fusion
Journal: Adv Sci (Weinh) | Authors: Xulong Ding | Species: mouse | Application: WB - DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice
Journal: Elife | Authors: Xiang Wang | Species: human | Application: WB,IF - PIH1D3-knockout rats exhibit full ciliopathy features and dysfunctional pre-assembly and loading of dynein arms in motile cilia
Journal: Front Cell Dev Biol | Authors: Tingting Zhang | Species: rat | Application: WB,IF - CCDC183 is essential for cytoplasmic invagination around the flagellum during spermiogenesis and male fertility
Journal: Development | Authors: Keisuke Shimada | Species: mouse | Application: WB - DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella.
Journal: Clin Genet | Authors: Yang Li | Species: human | Application: IF - Dnali1 is required for sperm motility and male fertility in mice
Journal: Basic Clin Androl | Authors: Yiling Zhou | Species: mouse | Application: WB,IF
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