4-Hydroxynonenal Monoclonal antibody 68538-1-Ig proteintech
$149.00
In stock
SKU
68538-1-Ig
| Catalog Number | 68538-1-Ig |
| Synonyms | 4-HNE, 4-Hydroxy-2-nonenal, C9H16O2, Cas. 75899-68-2 |
| Host | Mouse |
| Reactivity | 4-hydroxynonenal, chemical compound and More (3) |
| Reactivity | 4-hydroxynonenal, chemical compound, human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, IF, ELISA |
| Applications | ELISA |
| Host / Isotype | Mouse / IgG2a |
| Tested Applications — Positive ELISA detected in | 4-Hydroxynonenal |
| Positive ELISA detected in | 4-Hydroxynonenal |
| Enzyme-linked Immunosorbent Assay (ELISA) | ELISA : 1:5000-1:20000 |
| Tested Reactivity | 4-hydroxynonenal, chemical compound |
| Cited Reactivity | human, mouse, rat |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | Peptide Predict reactive species |
| Full Name | 4-Hydroxynonenal |
| RRID | AB_3085246 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| mouse | WB Adv Sci (Weinh) Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid-Induced Bone Loss Authors - Li-Jiang Han View Article |
| Citations | 29 |
| Dilutions | ELISA : 1:5000-1:20000 |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Clone Number | 2C1D10 |
| Conjugation | Unconjugated |
4-Hydroxynonenal is a uremic toxin. Uremic toxins can be subdivided into three major groups based upon their chemical and physical characteristics: 1) small, water-soluble, non-protein-bound compounds, such as urea; 2) small, lipid-soluble and/or protein-bound compounds, such as the phenols and 3) larger so-called middle-molecules, such as beta2-microglobulin. 4-Hydroxynonenal (4-HNE) is a major aldehydic product of ω-6-unsaturated fatty acid peroxidation. It is considered a lipid peroxidation specific marker. 4-HNE has been found to induce differentiation and inhibit proliferation of HL-60 human leukemic cells. It has also been found to induce murine alveolar macrophage cell death. 4-HNE has been shown to inhibit State 3 respiration, causing a transient cytosolic Ca2+ increase. In addition, it irreversibly inhibits Na+-K+-ATPase activity.
Publications
- Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered liver lipid metabolism on a ketogenic diet
Journal: Free Radic Biol Med | Authors: Guogang Xu | Species: mouse | Application: WB - HMGB1-mediated enhancement of glycolysis activates hepatic stellate cells by inhibiting ferroptosis in alcoholic hepatic fibrosis.
Journal: Stem Cell Res Ther | Authors: Yangyang Li | Species: mouse | Application: IF - Targeted Delivery of Schisandrin A to Cardiac Endothelium Alleviates Myocardial Ischemia-Reperfusion Injury via Suppression of Ferroptosis.
Journal: Int J Nanomedicine | Authors: Xue Guan - Aluminum exposure impairs nuclear envelope breakdown for mouse zygote formation.
Journal: iScience | Authors: Xiao-Ting Yu | Species: mouse | Application: IF - Biomimetic hybrid nanocarriers hitchhike neutrophils for targeted ginsenoside Rc delivery to BMSCs: ameliorating postmenopausal osteoporosis via iron homeostasis regulation.
Journal: J Nanobiotechnology | Authors: Yi He | Species: mouse | Application: WB - Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid-Induced Bone Loss
Journal: Adv Sci (Weinh) | Authors: Li-Jiang Han | Species: mouse | Application: WB - Identification of Pinostilbene as a natural STING agonist that triggers FTH1 degradation via K48-ubiquitination to induce ferroptosis in non-small cell lung cancer.
Journal: Redox Biol | Authors: Shuangshuang Song | Species: mouse | Application: IHC - Biomimetic hybrid nanocarriers hitchhike neutrophils for targeted ginsenoside Rc delivery to BMSCs: ameliorating postmenopausal osteoporosis via iron homeostasis regulation.
Journal: J Nanobiotechnology | Authors: Yi He | Species: mouse | Application: WB - Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid-Induced Bone Loss
Journal: Adv Sci (Weinh) | Authors: Li-Jiang Han | Species: mouse | Application: WB - Chemically Engineered L. reuteri Delivering αPD-L1 and Gallium Ions via Metal-Phenolic Networks Potentiate Anti-Tumor Immunity and Ferroptosis.
Journal: Adv Sci (Weinh) | Authors: Tingting Zhang | Species: mouse | Application: IHC - Molybdenum nanodots act as antioxidants for photothermal therapy osteoarthritis
Journal: Biomaterials | Authors: Guang Shi | Species: mouse | Application: IF - Fenofibrate targets PPARα-CPT1C axis to reverse aging by regulating lipid metabolism and mitochondrial function.
Journal: Pharmacol Res | Authors: Yanying Zhou | Species: human | Application: IF - Sulfur-Fumigation Engineered Ceria Nanoparticles With Augmented Oxygen Vacancies for Enhanced Therapy of Drug-Induced Liver Injury.
Journal: Small | Authors: Run Huang | Species: mouse | Application: IHC - Epigenetic suppression of Nrf2-Slc40a1 axis induces ferroptosis and enhances immunotherapy in pancreatic cancer.
Journal: J Immunother Cancer | Authors: Yixuan Zhang | Species: mouse | Application: IHC - Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Combined with PEG Hydrogel Alleviate Maternal Simulated Birth Injury in a Rat Model
Journal: Adv Healthc Mater | Authors: Qing Wang | Species: rat | Application: IHC - Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis.
Journal: Basic Res Cardiol | Authors: Zhuqing Li | Species: mouse | Application: IHC,IF - ETS transcription factor 1-insulin-like growth factor 2 mRNA-binding protein 2-interferon-induced transmembrane protein 3 pathway promotes ferroptosis-driven osteoblast senescence in diabetic osteoporosis.
Journal: Int J Biol Macromol | Authors: Xiao-Wei Liu | Species: mouse | Application: IF - Targeted Delivery of Schisandrin A to Cardiac Endothelium Alleviates Myocardial Ischemia-Reperfusion Injury via Suppression of Ferroptosis.
Journal: Int J Nanomedicine | Authors: Xue Guan - Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered liver lipid metabolism on a ketogenic diet
Journal: Free Radic Biol Med | Authors: Guogang Xu | Species: mouse | Application: WB - Sucralose promotes cardiac redox-metabolic remodeling through MRPL12-associated mitoribosomal stress.
Journal: Free Radic Biol Med | Authors: Ying Sun - HMGB1-mediated enhancement of glycolysis activates hepatic stellate cells by inhibiting ferroptosis in alcoholic hepatic fibrosis.
Journal: Stem Cell Res Ther | Authors: Yangyang Li | Species: mouse | Application: IF - HPD is a copper-binding protein that interacts with DLAT to promote colorectal cancer cuproptosis under copper stress
Journal: Cell Rep | Authors: Xintong Dai - Design, Synthesis, and Evaluation of Bibenzyl Analogues against Hepatocellular Carcinoma by Targeting Pyruvate Carboxylase.
Journal: J Med Chem | Authors: Zeen Qiao | Species: mouse | Application: IHC - PTK6 promotes ferroptosis resistance and CD8(+) T cell exhaustion in pancreatic tumors via reprogramming glucose and lipid metabolism.
Journal: Int Immunopharmacol | Authors: Rui Zheng | Species: mouse | Application: WB - Aluminum exposure impairs nuclear envelope breakdown for mouse zygote formation.
Journal: iScience | Authors: Xiao-Ting Yu | Species: mouse | Application: IF - Ceritinib induces ferroptosis via TRIM21-mediated GLUT1 ubiquitination and AMPK-driven metabolic reprogramming in breast cancer.
Journal: iScience | Authors: Yao Chen | Species: human | Application: IHC - LCN2-Driven Fibroblast Ferroptosis-Associated Injury Promotes Keratinocyte Proliferation via Lipid Peroxidation Signaling in Psoriasis.
Journal: FASEB J | Authors: Min Zhang | Species: mouse | Application: IF - Metallothionein 2A alleviates ulcerative colitis by inhibiting ferroptosis in intestinal epithelial cells with Tfrc downregulation
Journal: J Trace Elem Med Biol | Authors: Siqi Hua - EGFR suppression mediates aurantio-obtusin-induced autophagy-dependent ferroptosis in breast cancer cells.
Journal: Toxicol Appl Pharmacol | Authors: Yilin Wang - Exposure to Polystyrene Nanoplastics Induces Ferroptosis-Associated Cardiac Injury: Cell-Based Evidence for Lysosome-Associated NLRX1 Loss and an NLRX1-STING-NCOA4 Response.
Journal: Cardiovasc Toxicol | Authors: Guangzhen Lu | Species: mouse | Application: IHC - IGF2BP2 stabilizes SLC39A14 mRNA via m6A modification to promote ferroptosis in cerebral ischemia-reperfusion injury.
Journal: Arch Biochem Biophys | Authors: Haining Wang - FABP1-Mediated Lipid Metabolic Reprogramming Buffers Lipotoxicity in Nephrolithiasis via Maintaining PPARγ Activity.
Journal: FASEB J | Authors: Qiushi He | Species: mouse | Application: IHC - Exposure to Polystyrene Nanoplastics Induces Ferroptosis-Associated Cardiac Injury: Cell-Based Evidence for Lysosome-Associated NLRX1 Loss and an NLRX1-STING-NCOA4 Response.
Journal: Cardiovasc Toxicol | Authors: Guangzhen Lu | Species: mouse | Application: IHC - Bifidobacterium animalis subsp. lactis V9 overcomes CYFRA 21-1-linked immunochemotherapy resistance in NSCLC via microbial metabolites.
Journal: Sci Adv | Authors: Cuijiao Feng - Astrocytic FABP5 drives non-cell-autonomous oligodendrocyte injury in multiple system atrophy by promoting TNF signaling and ferroptotic stress.
Journal: Redox Biol | Authors: Chuantao Wu
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