TNFRSF21/DR6 Monoclonal antibody, PBS Only 66754-1-PBS proteintech
$699.00
In stock
SKU
66754-1-PBS
| Catalog Number | 66754-1-PBS |
| Synonyms | DR6, TNFRSF21, 3C2D10, CD358, Death receptor 6 |
| Host | Mouse |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | WB, IF/ICC, Indirect ELISA |
| Host / Isotype | Mouse / IgG1 |
| Tested Reactivity | human |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag14327 Product name: Recombinant human TNFRSF21 protein Source: e coli. -derived, T-HIS Tag: 6*His Domain: 365-655 aa of BC021572 Sequence: IVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLTVEPSPQDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHFLNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL Predict reactive species |
| Full Name | tumor necrosis factor receptor superfamily, member 21 |
| Calculated Molecular Weight | 655 aa, 72 kDa |
| Observed Molecular Weight | 69 kDa |
| GenBank Accession Number | BC021572 |
| Gene Symbol | DR6 |
| Gene ID (NCBI) | 27242 |
| RRID | AB_2882100 |
| Conjugate | Unconjugated |
| Purification Method | Protein G purification |
| UNIPROT ID | O75509 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
| Citations | - |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Clone Number | 3C2D10 |
| Conjugation | Unconjugated |
TNFRSF21 (also known as DR6 or CD358) is an orphan receptor of the tumor necrosis factor (TNF) receptor superfamily. It controls cell death and differentiation in a cell-autonomous manner in different cell types including neurons, oligodendrocytes, endothelial cells, and immune cells (PMID: 29459438). DR6 has been shown to activate NF-κB and JNK, and induce cell apoptosis (PMID: 9714541). DR6 interacts with TRADD, which is known to mediate signal transduction of TNF receptors. It has been reported that APP binds DR6 to trigger axon pruning and neuron death via distinct caspases, indicating that DR6 might be involved in Alzheimer's disease (PMID: 19225519).
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