Dystrophin Monoclonal antibody, PBS Only 68120-1-PBS proteintech
$699.00
In stock
SKU
68120-1-PBS
| Catalog Number | 68120-1-PBS |
| Synonyms | DMD, 1G12E6, BMD |
| Host | Mouse |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | WB, IHC, IF-P, FC (Intra), Indirect ELISA |
| Host / Isotype | Mouse / IgG2a |
| Tested Reactivity | human, mouse, rat |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag4392 Product name: Recombinant human DMD protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 286-635 aa of BC028720 Sequence: YPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE Predict reactive species |
| Full Name | dystrophin |
| Calculated Molecular Weight | 3685 aa, 427 kDa |
| Observed Molecular Weight | 70 kDa, 430 kDa |
| GenBank Accession Number | BC028720 |
| Gene Symbol | Dystrophin |
| Gene ID (NCBI) | 1756 |
| RRID | AB_2935256 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | P11532 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
| Citations | - |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Clone Number | 1G12E6 |
| Conjugation | Unconjugated |
Dystrophin (DMD or BMD) is a large muscle protein whose mutations cause Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), the childhood neuromuscular disorders that result in progressive muscle weakness, respiratory difficulties and cardiovascular dysfunction. Dystrophin is a crucial component of the dystrophin-glycoprotein complex which is essential for muscle membrane integrity and stability. Dystrophin is located on the cytoplasmic face of the sarcolemma and connects the cytoskeletal network to the sarcolemma and extracellular matrix. Multiple isoforms of dystrophin exist due to the alternative splicing, with a wide range of MW (69-72, 110-143, 271, 426 kDa). Most tissues contain transcripts of several isoforms. This antibody can recognize all the isoforms of Dystrophin.
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