ERCC6 Recombinant monoclonal antibody, PBS Only 86144-1-PBS proteintech
$699.00
In stock
SKU
86144-1-PBS
| Catalog Number | 86144-1-PBS |
| Synonyms | ARMD5, ATP dependent helicase ERCC6, Chimeric CSB-PGBD3 protein, Chimeric ERCC6-PGBD3 protein, CKN2 |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | WB, Indirect ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Reactivity | human |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | CatNo: Ag18009 Product name: Recombinant human ERCC6 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1144-1493 aa of BC127104 Sequence: DESIDEKLGLSYKRERPSQAQTEAFWENKQMENNFYKHKSKTKHHSVAEEETLEKHLRPKQKPKNSKHCRDAKFEGTRIPHLVKKRRYQKQDSENKSEAKEQSNDDYVLEKLFKKSVGVHSVMKHDAIMDGASPDYVLVEAEANRVAQDAPKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGKKSRFGKKRNSNFSVQHPSSTSPTEKCQDGIMKKEGKDNVPEHFSGRAEDADSSSGPLASSSLLAKMRARNHLILPERLESESGHLQEASALLPTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQSCVFRELLRNLCTFHRTSGGEGIWKLKPEYC Predict reactive species |
| Full Name | excision repair cross-complementing rodent repair deficiency, complementation group 6 |
| Calculated Molecular Weight | 1493 aa, 168 kDa |
| Observed Molecular Weight | 180 kDa |
| GenBank Accession Number | BC127104 |
| Gene Symbol | ERCC6/CSB |
| Gene ID (NCBI) | 2074 |
| RRID | AB_3744659 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | Q03468 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
| Citations | - |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 250645D4 |
| Conjugation | Unconjugated |
ERCC6, also named as CSB, belongs to the SNF2/RAD54 helicase family. It is involved in the preferential repair of active genes. It is presumed DNA or RNA unwinding function. ERCC6 corrects the UV survival and RNA synthesis after UV exposure of Cockayne syndrome complementation group B. Defects in ERCC6 are the cause of Cockayne syndrome type B (CSB) , cerebro-oculo-facio-skeletal syndrome type 1 (COFS1), De Sanctis-Cacchione syndrome (DSC), and UV-sensitive syndrome (UVS). Genetic variation in ERCC6 is associated with susceptibility to age-related macular degeneration type 5 (ARMD5). The antibody is specific to ERCC6.
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