EXOSC6 Polyclonal antibody 30685-1-AP proteintech
$149.00
In stock
SKU
30685-1-AP
| Catalog Number | 30685-1-AP |
| Synonyms | EAP4, EXOSC6, exosome component 6, hMtr3, hMtr3p, MTR3, Mtr3p, p11 |
| Host | Rabbit |
| Reactivity | Human |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | HaCaT cells, HeLa cells, HepG2 cells, Jurkat cells, K-562 cells, MCF-7 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:3000 |
| Positive WB detected in | HaCaT cells, HeLa cells, HepG2 cells, Jurkat cells, K-562 cells, MCF-7 cells |
| Western Blot (WB) | WB : 1:500-1:3000 |
| Tested Reactivity | Human |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag33513 Product name: Recombinant human EXOSC6 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-272 aa of NM_058219 Sequence: MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAGGTKVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFAGRRRRAPPGGCEERELALALQEALEPAVRLGRYPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYDLVVGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTESWAEAVRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP Predict reactive species |
| Full Name | exosome component 6 |
| Calculated Molecular Weight | 28kd |
| Observed Molecular Weight | 28-32 kDa |
| GenBank Accession Number | NM_058219 |
| Gene Symbol | EXOSC6 |
| Gene ID (NCBI) | 118460 |
| RRID | AB_3086386 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q5RKV6 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for EXOSC6 antibody 30685-1-AP | Download protocol |
| Citations | - |
| Dilutions | WB : 1:500-1:3000 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
EXOSC6 (exosome component 6), also known as p11 or MTR3. The calculated molecular weight of EXOSC6 is 28 kDa. And it has low tissue specificity. The gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. It is also a component of the RNA exosome complex (PMID: 29906447). The composition of human exosome is similar to its yeast counterpart. EXOSC6 is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. Protocols Product Specific Protocols WB protocol for EXOSC6 antibody 30685-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Product Documents
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
