FBXL6 Polyclonal antibody 33265-1-AP proteintech
$149.00
In stock
SKU
33265-1-AP
| Catalog Number | 33265-1-AP |
| Synonyms | FBL6, FBL6A, F-box and leucine-rich repeat protein 6, F-box protein FBL6, F-box/LRR-repeat protein 6 |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | 786-O cells, ACHN cells, HeLa cells, MCF-7 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:2000 |
| Positive WB detected in | 786-O cells, ACHN cells, HeLa cells, MCF-7 cells |
| Western Blot (WB) | WB : 1:500-1:2000 |
| Tested Reactivity | human |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag36604 Product name: Recombinant human FBXL6 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-182 aa of NM_012162.3 Sequence: MAAPASRQVRRRARAAPRPRSAEDWWWDRLAPRGSGYHLLQSDSMLLVLSEPGPARPRAQRRASRRTPRQPPRGPSAAAKPKAGLRSEAAAAPAPAPAPTPTPEEGPDAGWGDRIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSSPLVGRPAKGGVKAEKKLL Predict reactive species |
| Full Name | F-box and leucine-rich repeat protein 6 |
| Calculated Molecular Weight | 59kDa，539aa |
| Observed Molecular Weight | 60 kDa |
| GenBank Accession Number | NM_012162.3 |
| Gene Symbol | FBXL6 |
| Gene ID (NCBI) | 26233 |
| RRID | AB_3742921 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q8N531 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for FBXL6 antibody 33265-1-AP | Download protocol |
| Citations | - |
| Dilutions | WB : 1:500-1:2000 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
FBXL6 is an F-box/LRR-type E3 ubiquitin ligase that serves as the substrate-recognition subunit of the SCF complex. It stabilizes HSP90AA1 via K63-linked ubiquitination to activate c-MYC and drive hepatocellular carcinoma progression, while also degrading defective mitochondrial ribosomal proteins to preserve mitochondrial proteostasis. Its overexpression correlates with poor prognosis in renal and colorectal cancers and can promote cell proliferation by down-regulating RPL11 to activate the MDM2-p53 axis. Protocols Product Specific Protocols WB protocol for FBXL6 antibody 33265-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
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