HGS Recombinant monoclonal antibody, PBS Only 87420-1-PBS proteintech
$699.00
In stock
SKU
87420-1-PBS
| Catalog Number | 87420-1-PBS |
| Synonyms | Hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs, Protein pp110, ZFYVE8 |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | WB, IF/ICC, IP, Indirect ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Reactivity | human, mouse, rat |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | CatNo: Ag0589 Product name: Recombinant human HGS protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 186-387 aa of BC003565 Sequence: GQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASSAPPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIPPS Predict reactive species |
| Full Name | hepatocyte growth factor-regulated tyrosine kinase substrate |
| Calculated Molecular Weight | 86 kDa |
| Observed Molecular Weight | 110 kDa |
| GenBank Accession Number | BC003565 |
| Gene Symbol | HGS |
| Gene ID (NCBI) | 9146 |
| RRID | AB_3745532 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | O14964 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
| Citations | - |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 252813G1 |
| Conjugation | Unconjugated |
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS, synonyms: HRS, ZFYVE8) is a 110 to 115-kDa zinc finger phosphotyrosine protein inducible by stimulation with interleukin 2 (IL-2), granulocyte-macrophage colony-stimulating factor (GM-CSF) as well as hepatocyte growth factor (HGF), and is associated with signal-transducing adaptor molecule (STAM). HGS suppresses DNA synthesis upon stimulation with IL-2 and GM-CSF, counteracting STAM's function, which is critical for cell growth signaling mediated by the cytokines. HGS also interacts with the neurofibromatosis 2 tumor suppressor protein Schwannomin/merlin. The growth suppression activity of schwannoma/merlin requires HGS. The binding of schwannoma/merlin to HGS facilitates its ability to function as a tumor suppressor, probably by inhibiting STAT activation.
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