LONP1 Polyclonal antibody 15440-1-AP proteintech
$149.00
In stock
SKU
15440-1-AP
| Catalog Number | 15440-1-AP |
| Synonyms | EC:3.4.21.53, LON, LONP, LONP 1, Mitochondrial ATP-dependent protease Lon |
| Host | Rabbit |
| Reactivity | human, mouse, rat and More (2) |
| Reactivity | human, mouse, rat, monkey, chicken |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, IF/ICC, IP, CoIP, ELISA |
| Applications | WB, IHC, IF/ICC, IP, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | HeLa cells, human heart tissue, rat heart tissue, rat lung tissue, mouse heart tissue, Jurkat cells, mouse brain tissue, rat brain tissue |
| Tested Applications — Positive IP detected in | mouse heart tissue |
| Tested Applications — Positive IHC detected in | human lung cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Tested Applications — Positive IF/ICC detected in | HepG2 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:1000-1:6000 |
| Recommended Dilutions — Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Recommended Dilutions — Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| Positive WB detected in | HeLa cells, human heart tissue, rat heart tissue, rat lung tissue, mouse heart tissue, Jurkat cells, mouse brain tissue, rat brain tissue |
| Positive IP detected in | mouse heart tissue |
| Positive IHC detected in | human lung cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HepG2 cells |
| Western Blot (WB) | WB : 1:1000-1:6000 |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse, rat, monkey, chicken |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag7196 Product name: Recombinant human LONP1 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 614-959 aa of BC000235 Sequence: EQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTAMGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFARAFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSLTGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPDEQAEALAVER Predict reactive species |
| Full Name | lon peptidase 1, mitochondrial |
| Calculated Molecular Weight | 106 kDa |
| Observed Molecular Weight | 100 kDa |
| GenBank Accession Number | BC000235 |
| Gene Symbol | LONP1 |
| Gene ID (NCBI) | 9361 |
| RRID | AB_2137152 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P36776 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IF protocol for LONP1 antibody 15440-1-AP | Download protocol |
| IHC protocol for LONP1 antibody 15440-1-AP | Download protocol |
| IP protocol for LONP1 antibody 15440-1-AP | Download protocol |
| WB protocol for LONP1 antibody 15440-1-AP | Download protocol |
| human | WB Mol Cell Circadian Oscillation of Sulfiredoxin in the Mitochondria. Authors - In Sup Kil KD Validated View Article |
| monkey | WB,IF Nat Cell Biol MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control. Authors - Tim König View Article |
| Victor (Verified Customer) (08-10-2026) | Worked excellent for CRISPR KO validation in HeLa. Applications: Western Blot Primary Antibody Dilution: 1:1000 Cell Tissue Type: HeLa LONP1 Antibody Western Blot validation (1:1000 dilution) in HeLa (Cat no:15440-1-AP) |
| B (Verified Customer) (01-28-2023) | It is okay to detect endogenous LONP1 although there are weak non specific bands. Applications: Western Blot Primary Antibody Dilution: 1:2000 Cell Tissue Type: mouse cortex lysate LONP1 Antibody Western Blot validation (1:2000 dilution) in mouse cortex lysate (Cat no:15440-1-AP) |
| Citations | 136 |
| Dilutions | WB : 1:1000-1:6000 IP : 0.5-4.0 ug for IP and 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate for WB IHC : 1:50-1:500 IF/ICC : 1:50-1:500 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
LONP1(Lon protease homolog, mitochondrial) is also named as LONP, LONHS, HLON, LON, PRSS15, PIM1, MGC1498 and belongs to the peptidase S16 family. It seems to play a major role in the elimination of oxidatively modified proteins in the mitochondrial matrix(PMID:18021745). LONP1, also a nuclearly encoded and mitochondrially located stress-responsive protease, is involved in heme-mediated ALAS-1 turnover(PMID:21659532). It recognizes specific surface determinants or folds, initiates proteolysis at solvent-accessible sites, and generates unfolded polypeptides that are then progressively degraded(PMID:15870080). LONP1 has some isoforms with the MW of 106 kDa, 100 kDa and 86 kDa. Protocols Product Specific Protocols IF protocol for LONP1 antibody 15440-1-AP Download protocol IHC protocol for LONP1 antibody 15440-1-AP Download protocol IP protocol for LONP1 antibody 15440-1-AP Download protocol WB protocol for LONP1 antibody 15440-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- A cytosolic surveillance mechanism activates the mitochondrial UPR
Journal: Nature | Authors: F X Reymond Sutandy KD Validated | Species: human | Application: WB - A High-Density Human Mitochondrial Proximity Interaction Network.
Journal: Cell Metab | Authors: Hana Antonicka | Species: human | Application: WB - LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes
Journal: Nat Metab | Authors: Jin Li KO Validated - MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.
Journal: Nat Cell Biol | Authors: Tim König | Species: monkey | Application: WB,IF - The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism
Journal: Mol Cell | Authors: Wang Jiahui KD Validated | Species: human | Application: WB - Circadian Oscillation of Sulfiredoxin in the Mitochondria.
Journal: Mol Cell | Authors: In Sup Kil KD Validated | Species: human | Application: WB - MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.
Journal: Nat Cell Biol | Authors: Tim König | Species: monkey | Application: WB,IF - The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence.
Journal: Nat Neurosci | Authors: Maria Jose Perez J - Disrupting α-Synuclein-ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson's disease models.
Journal: Mol Neurodegener | Authors: Di Hu | Species: human | Application: WB - Mitochondrial dynamics and quality control regulate proteostasis in neuronal ischemia-reperfusion
Journal: Autophagy | Authors: Garrett M Fogo | Species: mouse | Application: WB - Spatiotemporal Ca2+ nanodomain remodeling at MERCS regulates mitochondrial proteostasis
Journal: Protein Cell | Authors: Yanan Lv | Application: WB - Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength.
Journal: Nat Commun | Authors: Zhisheng Xu | Species: mouse | Application: WB - LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding.
Journal: Nat Commun | Authors: Chun-Shik Shin | Species: human | Application: WB,IP - Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism
Journal: Nat Commun | Authors: Claudio Bussi | Species: human | Application: WB - Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease
Journal: Nat Commun | Authors: Jun Dong | Species: mouse | Application: WB - Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis.
Journal: Nat Commun | Authors: Vaibhav Sidarala | Species: mouse | Application: WB - Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength.
Journal: Nat Commun | Authors: Zhisheng Xu | Species: mouse | Application: WB - Gestational exposure to PM(2.5) impaired cardiac development through ANGPTL4-mediated mitochondrial metabolic dysfunction.
Journal: J Adv Res | Authors: Jianong Lv | Species: human, mouse | Application: IF - Tau-induced mitochondrial reverse electron transport drives neurodegeneration.
Journal: Neuron | Authors: Wen Li - Mitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans
Journal: Redox Biol | Authors: Johannes CW Hermeling | Application: WB - The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism
Journal: Mol Cell | Authors: Wang Jiahui | Species: human | Application: WB - Circadian Oscillation of Sulfiredoxin in the Mitochondria.
Journal: Mol Cell | Authors: In Sup Kil | Species: human | Application: WB - DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.
Journal: Nucleic Acids Res | Authors: Pedro Silva-Pinheiro | Species: mouse | Application: WB - Dual-responsive nanoparticles targeting ACE-II senescence for therapeutic mitigation of acute lung injury
Journal: J Nanobiotechnology | Authors: Linlin Gao | Species: mouse | Application: WB - AMPK Suppression Due to Obesity Drives Oocyte mtDNA Heteroplasmy via ATF5-POLG Axis
Journal: Adv Sci (Weinh) | Authors: Yanting Chen | Species: mouse | Application: WB - Fidelity of translation initiation is required for coordinated respiratory complex assembly.
Journal: Sci Adv | Authors: Danielle L Rudler | Species: mouse | Application: WB - Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4.
Journal: Sci Adv | Authors: Qiqi Guo | Species: mouse | Application: WB,IHC - Imbalanced Skeletal Muscle Mitochondrial Proteostasis Causes Bone Loss
Journal: Research (Wash D C) | Authors: Zhen Jin | Species: mouse | Application: WB - Lon protease 1-mediated metabolic reprogramming promotes the progression of prostate cancer
Journal: Cell Death Dis | Authors: Mengfei Yao | Species: mouse,human | Application: WB,IHC,CoIP - Dual targeting of the mitochondrial Lon peptidase 1 and the chymotrypsin-like proteasome activity as a potential therapeutic strategy in malignant astrocytoma models
Journal: Pharmacol Res | Authors: Christopher Douglas | Species: mouse | Application: WB - Enhanced mitochondrial biogenesis facilitates the development of cutaneous squamous cell carcinoma
Journal: Cancer Lett | Authors: Ziyang Wang | Species: human | Application: WB,IP,IHC - Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1G93A Mice.
Journal: Int J Biol Sci | Authors: Qi Zhou | Species: mouse | Application: WB - Baicalin attenuates neuronal damage associated with SDH activation and PDK2-PDH axis dysfunction in early reperfusion
Journal: Phytomedicine | Authors: Kaili Liu | Species: mouse | Application: IF - The mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammals
Journal: EBioMedicine | Authors: Xiaoqiang Sheng | Species: mouse,human | Application: IP - Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.
Journal: Mol Psychiatry | Authors: María José Pérez | Species: human | Application: WB - CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis
Journal: Cell Death Discov | Authors: Lei Shi | Species: mouse | Application: WB - A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease
Journal: Acta Neuropathol | Authors: Yutong Shang | Species: mouse | Application: WB - Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.
Journal: Acta Neuropathol | Authors: Di Hu | Species: mouse,human | Application: WB - Micheliolide attenuates sepsis-induced acute lung injury by suppressing mitochondrial oxidative stress and PFKFB3-driven glycolysis
Journal: J Transl Med | Authors: Wenhan Li | Species: mouse | Application: WB - A traditional gynecological medicine inhibits ovarian cancer progression and eliminates cancer stem cells via the LRPPRC-OXPHOS axis
Journal: J Transl Med | Authors: Ruibin Jiang | Species: human | Application: WB - Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway.
Journal: Proc Natl Acad Sci U S A | Authors: Qi-Qiang Guo | Species: human, mouse | Application: WB,IP,CoIP - RNA-sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.
Journal: Diabetes | Authors: Miriam Cnop - HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis
Journal: Dev Cell | Authors: Xiang Peng | Species: human - A novel mitochondrial unfolded protein response-related risk signature to predict prognosis, immunotherapy and sorafenib sensitivity in hepatocellular carcinoma
Journal: Apoptosis | Authors: Sidi Zhang | Species: human | Application: WB - Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis
Journal: Apoptosis | Authors: Yao Zhou | Species: human | Application: WB - N6-methyladenosine (m(6)A) modification regulates LONP1 to inhibit coxsackievirus B3 replication by suppressing virus-induced ferroptosis.
Journal: Int J Biol Macromol | Authors: Qimeng Wang | Species: human | Application: WB - A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease
Journal: EMBO J | Authors: Yu Cao | Species: mouse | Application: WB - ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Journal: EMBO J | Authors: Li Shu | Species: human | Application: WB - ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Journal: EMBO J | Authors: Li Shu | Species: human | Application: WB - Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation.
Journal: EMBO J | Authors: Nicola Ferreira | Species: mouse | Application: WB - Toxicity of Necrostatin-1 in Parkinson's Disease Models.
Journal: Antioxidants (Basel) | Authors: Eva Alegre-Cortés | Species: human | Application: WB - A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Journal: Cell Mol Gastroenterol Hepatol | Authors: Dayan Sun | Species: human | Application: WB - Inhibiting VDAC1 oligomerization attenuated cerebral ischemia-reperfusion injury by promoting mitophagy via reduced LONP1 interaction.
Journal: Free Radic Biol Med | Authors: Xiangna Guo - From collapse to comeback: Luteolin rejuvenates nucleus pulposus progenitor cells via SIRT1/ATF5-UPRmt to reverse intervertebral disc degeneration cascade.
Journal: Stem Cell Res Ther | Authors: Huofeng Wu | Species: rat,human | Application: WB,IHC - A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.
Journal: Cell Rep | Authors: Kenneth Robert Pryde | Species: human | Application: WB - Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Journal: Cell Rep | Authors: Fenglei Jian | Species: human | Application: WB - NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP
Journal: Cell Rep | Authors: Liang Lv | Species: human | Application: WB - The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response
Journal: Cell Rep | Authors: Douja Chamseddine | Species: mouse | Application: WB - Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.
Journal: Br J Pharmacol | Authors: Miriam Polo | Species: human | Application: IF - Intake of flavonoids from Astragalus membranaceus ameliorated brain impairment in diabetic mice via modulating brain-gut axis.
Journal: Chin Med | Authors: Xuling Li | Species: mouse | Application: WB - LONP1 facilitates pulmonary artery smooth muscle cell glycolytic reprogramming by degrading MPC1 in pulmonary hypertension
Journal: Clin Sci (Lond) | Authors: Mingkang Li | Species: rat,mouse | Application: WB,IHC,IF - Shugan Tongbian Decoction ameliorates constipation and mental disorder by inhibiting UPR(mt) via Wnt/Retromer axis.
Journal: J Ethnopharmacol | Authors: Jiali Liu | Species: rat | Application: WB - Xinyang tablet alleviated cardiac dysfunction in a cardiac pressure overload model by regulating the receptor-interacting serum/three-protein kinase 3/FUN14 domain containing 1-mediated mitochondrial unfolded protein response and mitophagy
Journal: J Ethnopharmacol | Authors: Xin Dong | Species: mouse | Application: WB - Mitochondrial oxidative stress regulates LonP1-TDP-43 pathway and rises mitochondrial damage in carbon tetrachloride-induced liver fibrosis
Journal: Ecotoxicol Environ Saf | Authors: Shulin Shan | Species: mouse | Application: WB,IF - Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2
Journal: Biochem Pharmacol | Authors: Xiaohui Sun | Species: human | Application: WB - BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson's disease
Journal: Acta Neuropathol Commun | Authors: Aya Jishi | Species: human | Application: WB - Identification of a Novel c-Myc Inhibitor 7594-0037 by Structure-Based Virtual Screening and Investigation of Its Anti-Cancer Effect on Multiple Myeloma.
Journal: Drug Des Devel Ther | Authors: Ruosi Yao | Species: human | Application: WB - Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z.
Journal: EMBO Rep | Authors: Stefan J Siira - CDDO-Me Selectively Attenuates CA1 Neuronal Death Induced by Status Epilepticus via Facilitating Mitochondrial Fission Independent of LONP1.
Journal: Cells | Authors: Ji-Eun Kim | Species: rat | Application: WB,IF - Wen-Shen-Tong-Luo-Zhi-Tong Decoction alleviates bone loss in aged mice by suppressing LONP1-mediated macrophage senescence
Journal: Pharm Biol | Authors: Qinfeng Zhou | Species: mouse | Application: IHC - TRPC6-Mediated ERK1/2 Activation Increases Dentate Granule Cell Resistance to Status Epilepticus Via Regulating Lon Protease-1 Expression and Mitochondrial Dynamics.
Journal: Cells | Authors: Ji-Eun Kim | Species: rat | Application: WB,IF - UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy
Journal: EMBO Rep | Authors: Jing Zheng | Species: human - Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix.
Journal: Commun Biol | Authors: Yuichi Matsushima | Species: human | Application: WB,IP - Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway
Journal: Commun Biol | Authors: Paul Y Bi | Species: human | Application: WB - The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy
Journal: Cell Biol Toxicol | Authors: Wen-Ning Xu | Species: rat | Application: IHC,IF - The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress.
Journal: Cell Biol Toxicol | Authors: Sokhna M S Yakhine-Diop | Species: human | Application: WB - Involvement of Melatonin, Oxidative Stress, and Inflammation in the Protective Mechanism of the Carotid Artery over the Torpor-Arousal Cycle of Ground Squirrels
Journal: Int J Mol Sci | Authors: Ziwei Hao | Application: WB - miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.
Journal: Int J Mol Sci | Authors: Ya-Ling Yang | Species: mouse | Application: WB - Readdressing the Localization of Apolipoprotein E (APOE) in Mitochondria-Associated Endoplasmic Reticulum (ER) Membranes (MAMs): An Investigation of the Hepatic Protein-Protein Interactions of APOE with the Mitochondrial Proteins Lon Protease (LONP1), Mitochondrial Import Receptor Subunit TOM40 (TOMM40) and Voltage-Dependent Anion-Selective Channel 1 (VDAC1)
Journal: Int J Mol Sci | Authors: Johanna Rueter | Species: human | Application: WB - Involvement of Melatonin, Oxidative Stress, and Inflammation in the Protective Mechanism of the Carotid Artery over the Torpor-Arousal Cycle of Ground Squirrels
Journal: Int J Mol Sci | Authors: Ziwei Hao | Application: WB - miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.
Journal: Int J Mol Sci | Authors: Ya-Ling Yang | Species: mouse | Application: WB - Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha.
Journal: Int J Mol Sci | Authors: Ya-Ling Yang | Species: mouse | Application: WB - Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism
Journal: Biol Direct | Authors: Akihiro Yamashita | Species: human | Application: WB - Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson's Disease Patients.
Journal: Mol Neurobiol | Authors: Sokhna M S Yakhine-Diop | Species: human | Application: WB - Astrocytic-HSP60 Depletion Contributed to Autophagy Defects of Astrocytes and Depressive-Like Behaviors in Male Mice
Journal: Glia | Authors: Weifen Li | Species: mouse | Application: WB - ATF4 Mediates Mitochondrial Unfolded Protein Response (UPRmt) in Alveolar Epithelial Cells.
Journal: Am J Respir Cell Mol Biol | Authors: Dingyuan Jiang | Species: human | Application: WB,IF - Deciphering LonP1's Role in Glioblastoma: An Alternative Mechanism of Treatment Resistance.
Journal: Am J Physiol Cell Physiol | Authors: Shashi Jain - Single-cell transcriptomics uncovering a critical AKT-LONP1-STAR axis in ovarian hyperandrogenism of PCOS.
Journal: J Ovarian Res | Authors: Chunren Zhang | Species: mouse | Application: WB - Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability.
Journal: Biochim Biophys Acta Mol Basis Dis | Authors: Zixing Fu | Species: human | Application: WB - Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels.
Journal: Oxid Med Cell Longev | Authors: Reiko Iida | Species: human | Application: WB - Altered mitochondrial unfolded protein response and FGF21 secretion in MASLD progression and the effect of exercise intervention
Journal: Sci Rep | Authors: Xinmeng Yuan | Species: mouse | Application: WB - Zinc enhances the cellular energy supply to improve cell motility and restore impaired energetic metabolism in a toxic environment induced by OTA.
Journal: Sci Rep | Authors: Xuan Yang | Species: human | Application: WB - CDC25C downregulation suppresses HCC growth via mitochondrial stress-induced autophagy and apoptosis.
Journal: Sci Rep | Authors: Xinyu Miao | Species: mouse | Application: WB - Unfolded proteins in the mitochondria activate HRI and inhibit mitochondrial protein translation
Journal: Cell Signal | Authors: Yongshu Wu | Species: human | Application: WB - Decreased activity of the 20S proteasome in the brain white matter and gray matter of patients with multiple sclerosis.
Journal: J Neurochem | Authors: Zheng Jianzheng J | Species: human | Application: WB - Calpain-Inhibitors Protect Frataxin-Deficient Dorsal Root Ganglia Neurons from Loss of Mitochondrial Na+/Ca2+ Exchanger, NCLX, and Apoptosis.
Journal: Neurochem Res | Authors: Elena Britti | Species: rat | Application: WB - Calpain-Inhibitors Protect Frataxin-Deficient Dorsal Root Ganglia Neurons from Loss of Mitochondrial Na+/Ca2+ Exchanger, NCLX, and Apoptosis.
Journal: Neurochem Res | Authors: Elena Britti | Species: rat | Application: WB - The synthetic oleanane triterpenoid CDDO-2P-Im binds GRP78/BiP to induce unfolded protein response-mediated apoptosis in myeloma
Journal: Mol Oncol | Authors: George Luo | Species: human | Application: WB - Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice.
Journal: Front Cell Neurosci | Authors: Yang Shen | Species: mouse,human | Application: WB - Fibroblast growth factor 7 protects osteoblasts against oxidative damage through targeting mitochondria
Journal: FASEB J | Authors: Xiaoyu Liu | Species: mouse,human | Application: WB - Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma.
Journal: Am J Physiol Endocrinol Metab | Authors: John O Ogunbileje | Species: human | Application: WB - Exercise attenuates polycystic ovary syndrome development via improved mitochondrial proteostasis.
Journal: Am J Physiol Endocrinol Metab | Authors: Chaeyoung Shin | Species: mouse | Application: WB - An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
Journal: J Biol Chem | Authors: Xiaofen Jin | Species: human | Application: WB - Peste des petits ruminants virus (PPRV) induces ferroptosis via LONP1-mediated mitochondrial GPX4 degradation in cell culture
Journal: J Virol | Authors: Qiaodi Hou | Species: human | Application: WB - Deafness-associated tRNAPhe mutation impaired mitochondrial and cellular integrity
Journal: J Biol Chem | Authors: Xiaowan Chen | Species: human | Application: WB - Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP -binding and -hydrolysis via CDDO and its derivatives.
Journal: J Biol Chem | Authors: Jae Lee | Species: human | Application: WB - LONP1 Promotes Hepatocarcinogenesis by Degrading ACO2 to Alleviate Ferroptosis
Journal: Front Biosci (Landmark Ed) | Authors: Yanfeng Zhong | Application: WB,IHC - MAGMAS Inhibition Enhances Temozolomide Efficacy in Chemotherapy-Resistant Glioblastoma Models.
Journal: Cancer Res Commun | Authors: Javier J. Lepe | Species: human | Application: WB - TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
Journal: PLoS Genet | Authors: Peng Wang | Species: human | Application: WB - Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia.
Journal: Biochem J | Authors: Elena Britti | Species: rat | Application: WB - UPRmt alleviates bone cancer pain through the restoration of mitochondrial function
Journal: Exp Cell Res | Authors: Dan Li | Species: mouse | Application: WB - SIRT6 attenuates LPS-induced inflammation and apoptosis of lung epithelial cells in acute lung injury through ACE2/STAT3/PIM1 signaling
Journal: Immun Inflamm Dis | Authors: Juan Yang | Species: mouse,human | Application: WB - Inhibition of human peptide deformylase by actinonin sensitizes glioblastoma cells to temozolomide chemotherapy
Journal: Exp Cell Res | Authors: Beiwu Lan | Species: human | Application: WB - Central role of Nix in the autophagic response to ochratoxin A.
Journal: Food Chem Toxicol | Authors: Xiao Li Shen | Species: human | Application: WB - Excessive ER-phagy contributes to ochratoxin A-induced apoptosis
Journal: Food Chem Toxicol | Authors: Huiqiong Deng | Species: human | Application: WB - Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Journal: IUBMB Life | Authors: Haohan Zhou | Species: mouse | Application: WB - Central role of Nix in the autophagic response to ochratoxin A.
Journal: Food Chem Toxicol | Authors: Xiao Li Shen | Species: human | Application: WB - Mitochondrial DNA Haplogroup M7 Confers Disability in a Chinese Aging Population.
Journal: Front Genet | Authors: Dayan Sun | Species: human | Application: WB - Melatonin Protects Against Mitochondrial Dyshomeostasis and Ovarian Damage Caused by Chronic Unpredictable Mild Stress Through the eIF2α-AFT4 Signaling Pathway in Mice
Journal: Reprod Sci | Authors: Si-Min Ding | Species: mouse | Application: WB - The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells.
Journal: PLoS One | Authors: Moore Fabrice F | Species: rat | Application: WB - Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy.
Journal: Biomed Pharmacother | Authors: Fengbo Wu | Species: mouse | Application: WB - Age-related changes in the mitochondrial, synthesis of steroids, and cellular homeostasis of the chicken ovary
Journal: Anim Reprod Sci | Authors: Xiao-Zhi Zhan | Species: chicken | Application: WB - Decreased LONP1 expression contributes to DNA damage and meiotic defects in oocytes
Journal: Mol Reprod Dev | Authors: Chuanming Liu | Species: mouse | Application: CoIP - miR-542-3p suppresses invasion and metastasis by targeting the proto-oncogene serine/threonine protein kinase, PIM1, in melanoma.
Journal: Biochem Biophys Res Commun | Authors: Zhen Rang - UPRmt activation protects against MPP+-induced toxicity in a cell culture model of Parkinson's disease.
Journal: Biochem Biophys Res Commun | Authors: Di Hu | Species: human | Application: WB - CD36 regulates myogenic differentiation via chronic integrated stress response - implications for muscle aging.
Journal: J Muscle Res Cell Motil | Authors: Xin Ye | Species: mouse | Application: WB - SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin.
Journal: Genes Genomics | Authors: Hao Chen | Species: human | Application: WB - Hypoxia-induced LONP1 overexpression and mtDNA damage may serve as biomarkers for death from mechanical asphyxia.
Journal: Leg Med (Tokyo) | Authors: Tianpu Wu | Species: human | Application: WB - Tau-induced mitochondrial reverse electron transport drives neurodegeneration.
Journal: bioRxiv | Authors: Wen Li - Targeting the ClpP-αSynuclein Interaction with a Decoy Peptide to Mitigate Neuropathology in Parkinson's Disease Models
Journal: bioRxiv | Authors: Di Hu | Species: human | Application: WB - Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function
Journal: bioRxiv | Authors: David R Rawnsley | Species: mouse,human | Application: WB - Mitochondrial degradation of metallothionein enables local zinc mobilization during zinc limitation.
Journal: bioRxiv | Authors: Austin K. Murchison - Mitochondrial degradation of metallothionein enables local zinc mobilization during zinc limitation.
Journal: bioRxiv | Authors: Austin K. Murchison - Tau-induced mitochondrial reverse electron transport drives neurodegeneration.
Journal: bioRxiv | Authors: Wen Li - Targeting the ClpP-αSynuclein Interaction with a Decoy Peptide to Mitigate Neuropathology in Parkinson's Disease Models
Journal: bioRxiv | Authors: Di Hu | Species: human | Application: WB - Discovery and Validation of Novel LonP1 and Proteasome Inhibitor in IDH1-R132H Malignant Astrocytoma Models
Journal: bioRxiv | Authors: Christopher Douglas | Species: human | Application: WB
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