IL-17RA Recombinant monoclonal antibody 84535-2-RR proteintech
$149.00
In stock
SKU
84535-2-RR
| Catalog Number | 84535-2-RR |
| Synonyms | CD217, IL17RA, 241891E11, CANDF5, CDw217 |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, IF/ICC, FC, ELISA |
| Applications | WB, IHC, IF/ICC, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | THP-1 cells, Jurkat cells, K-562 cells, MOLT-4 cells, U-937 cells, Raji cells, U2OS cells |
| Tested Applications — Positive IHC detected in | Human Tonsil tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Tested Applications — Positive IF/ICC detected in | U-937 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:2000 |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:500-1:2000 |
| Recommended Dilutions — Immunofluorescence (IF)/ICC | IF/ICC : 1:200-1:800 |
| Positive WB detected in | THP-1 cells, Jurkat cells, K-562 cells, MOLT-4 cells, U-937 cells, Raji cells, U2OS cells |
| Positive IHC detected in | Human Tonsil tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | U-937 cells |
| Western Blot (WB) | WB : 1:500-1:2000 |
| Immunohistochemistry (IHC) | IHC : 1:500-1:2000 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:200-1:800 |
| Tested Reactivity | human |
| Cited Reactivity | human |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | CatNo: Eg2317 Product name: Recombinant Human IL-17RA protein (rFc Tag) Source: mammalian cells -derived, pHZ-KIsec-C-rFc Tag: C-rFc Domain: 33-320 aa of BC011624 Sequence: LRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLW Predict reactive species |
| Full Name | interleukin 17 receptor A |
| Calculated Molecular Weight | 866 aa, 96 kDa |
| Observed Molecular Weight | 100-130 kDa |
| GenBank Accession Number | BC011624 |
| Gene Symbol | IL17RA |
| Gene ID (NCBI) | 23765 |
| RRID | AB_3672042 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purification |
| UNIPROT ID | Q96F46 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IF protocol for IL-17RA antibody 84535-2-RR | Download protocol |
| IHC protocol for IL-17RA antibody 84535-2-RR | Download protocol |
| WB protocol for IL-17RA antibody 84535-2-RR | Download protocol |
| human | IF, FC Front Pharmacol Anti-inflammatory effect of novel polypeptide WMX-8 through specific blockade of the IL17RA signaling pathway. Authors - Xinmin Wang KD Validated View Article |
| Citations | 1 |
| Dilutions | WB : 1:500-1:2000 IHC : 1:500-1:2000 IF/ICC : 1:200-1:800 |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 241891E11 |
| Conjugation | Unconjugated |
Interleukin-17 receptor A (IL17A) is a major effector cytokine of the innate and adaptive immune system and is involved in antimicrobial host defense and maintenance of tissue integrity. It has been shown that IL-17A is involved in the pathogenesis of asthma and allergy and regulates local immune and inflammatory processes in bone tissue and is involved in the onset and progression of osteoporosis. In addition to this, due to polymorphisms in the IL17RA gene, it leads to the development of Fanconi anemia. Protocols Product Specific Protocols IF protocol for IL-17RA antibody 84535-2-RR Download protocol IHC protocol for IL-17RA antibody 84535-2-RR Download protocol WB protocol for IL-17RA antibody 84535-2-RR Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Anti-inflammatory effect of novel polypeptide WMX-8 through specific blockade of the IL17RA signaling pathway.
Journal: Front Pharmacol | Authors: Xinmin Wang KD Validated | Species: human | Application: IF, FC
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