IL-4RA/CD124 Monoclonal antibody, PBS Only (Capture/Detector) 67051-3-PBS proteintech
$699.00
In stock
SKU
67051-3-PBS
| Catalog Number | 67051-3-PBS |
| Synonyms | IL4R, IL 4R subunit alpha, IL 4R alpha, IL 4 receptor subunit alpha, IL 4 binding protein |
| Host | Mouse |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | Cytometric bead array, Indirect ELISA |
| Host / Isotype | Mouse / IgM |
| Tested Reactivity | human |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag28411 Product name: Recombinant human IL-4R protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 26-232 aa of NM_000418 Sequence: MKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQH Predict reactive species |
| Full Name | interleukin 4 receptor |
| Calculated Molecular Weight | 90 kDa |
| GenBank Accession Number | NM_000418 |
| Gene Symbol | IL-4R |
| Gene ID (NCBI) | 3566 |
| Conjugate | Unconjugated |
| Purification Method | Euglobulin precipitation |
| UNIPROT ID | P24394 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
| Citations | - |
| Isotype | IgM |
| Clonality | Monoclonal |
| Clone Number | 3F12E8 |
| Conjugation | Unconjugated |
IL-4 receptor alpha chain (IL-4RA), also known as CD124, is a transmembrane glycoprotein expressed on a wide variety of hematopoietic and non-hematopoietic cells. It is a receptor for both IL-4 and IL-13. IL-4RA can complex with the common gamma chain (IL-2R gamma or CD132) and utilizes JAK1 and JAK2 for signal transduction, while complexes of IL-4RA with IL-13RA1 subunit mediate signals via JAK2 and Tyk2. The IL-4 response is involved in promoting Th2 differentiation. The IL-4/IL-13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation.
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