ITM2B Polyclonal antibody 12193-1-AP proteintech
$149.00
In stock
SKU
12193-1-AP
| Catalog Number | 12193-1-AP |
| Synonyms | ABRI, Bri, BRI2, BRI2 intracellular domain, BRI2, membrane form |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | U-251 cells, fetal human brain tissue, U-251 cells unboiled |
| Tested Applications — Positive IHC detected in | mouse kidney tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Recommended Dilutions — Western Blot (WB) | WB : 1:1000-1:4000 |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Positive WB detected in | U-251 cells, fetal human brain tissue, U-251 cells unboiled |
| Positive IHC detected in | mouse kidney tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Western Blot (WB) | WB : 1:1000-1:4000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Tested Reactivity | human |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag2831 Product name: Recombinant human ITM2B protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-266 aa of BC016148 Sequence: MVKVTFNSALAQKETKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS Predict reactive species |
| Full Name | integral membrane protein 2B |
| Calculated Molecular Weight | 266 aa, 30 kDa |
| Observed Molecular Weight | 40 kDa |
| GenBank Accession Number | BC016148 |
| Gene Symbol | ITM2B |
| Gene ID (NCBI) | 9445 |
| RRID | AB_3669134 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9Y287 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IHC protocol for ITM2B antibody 12193-1-AP | Download protocol |
| WB protocol for ITM2B antibody 12193-1-AP | Download protocol |
| Citations | - |
| Dilutions | WB : 1:1000-1:4000 IHC : 1:50-1:500 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
ITM2B plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. It plays a role in the induction of neurite outgrowth and functions as a protease inhibitor by blocking access of secretases to APP cleavage sites. Protocols Product Specific Protocols IHC protocol for ITM2B antibody 12193-1-AP Download protocol WB protocol for ITM2B antibody 12193-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
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