Iduronate 2 sulfatase Monoclonal antibody, PBS Only 66112-1-PBS proteintech
$699.00
In stock
SKU
66112-1-PBS
| Catalog Number | 66112-1-PBS |
| Synonyms | IDS, 1A3F9, Alpha-L-iduronate sulfate sulfatase, EC:3.1.6.13, Iduronate 2-sulfatase |
| Host | Mouse |
| Reactivity | human, mouse, rat, pig |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | WB, IHC, IF/ICC, Indirect ELISA |
| Host / Isotype | Mouse / IgG1 |
| Tested Reactivity | human, mouse, rat, pig |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag19095 Product name: Recombinant human IDS protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-312 aa of BC006170 Sequence: MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQEDQSSTGFRLKTSSTRKYK Predict reactive species |
| Full Name | iduronate 2-sulfatase |
| Calculated Molecular Weight | 312aa,35 kDa; 550aa,62 kDa |
| Observed Molecular Weight | 76 kDa, 55 kDa |
| GenBank Accession Number | BC006170 |
| Gene Symbol | IDS |
| Gene ID (NCBI) | 3423 |
| RRID | AB_2881511 |
| Conjugate | Unconjugated |
| Purification Method | Protein G purification |
| UNIPROT ID | P22304 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
| Citations | - |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Clone Number | 1A3F9 |
| Conjugation | Unconjugated |
Iduronate 2-sulfatase (IDS) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations causing IDS deficiency in humans result in the lysosomal storage of these glycosaminoglycans and Hunter syndrome, an X chromosome-linked disease. IDS is synthesized as two precursor forms of 76 and 90 kDa that are converted, through a 62 kDa intermediate, to 55 and 45 kDa mature polypeptides due to an internal proteolytic cleavage (PMID: 10838181).
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