Anti-Mouse LAG-3/CD223 Rabbit Recombinant Antibody, PBS Only 98167-1-PBS proteintech
$472.00
In stock
SKU
98167-1-PBS
| Catalog Number | 98167-1-PBS |
| Synonyms | CD223, LAG-3, Ly66, Lag3, LAG 3 |
| Host | Rabbit |
| Reactivity | mouse |
| Form | Liquid |
| Formulation | PBS Only |
| Applications | FC |
| Host / Isotype | Rabbit / IgG |
| Tested Reactivity | mouse |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Fusion Protein Predict reactive species |
| Full Name | lymphocyte-activation gene 3 |
| Calculated Molecular Weight | 57 kDa |
| GenBank Accession Number | NM_008479.2 |
| Gene Symbol | CD223 |
| Gene ID (NCBI) | 16768 |
| RRID | AB_3672310 |
| Conjugate | Unconjugated |
| Purification Method | Protein A purfication |
| UNIPROT ID | Q61790 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
| Citations | - |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 241294E11 |
| Conjugation | Unconjugated |
Lymphocyte activation gene 3 protein (LAG-3), also known as CD223, is a type I transmembrane protein belonging to the immunoglobulin superfamily (PMID: 1692078). It is a CD4-related molecule that binds MHC class II with high affinity (PMID: 1692078; 9159144). LAG-3 is expressed on activated T and NK cells. Besides, natural CD4(+)CD25(+) Tregs express LAG-3 upon activation (PMID: 15485628). LAG-3 negatively regulates T-cell function and homeostasis, and contributes to the suppressor activity of Tregs (PMID: 14644131; 15485628).
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